Recent progress of therapeutic peptide based nanomaterials: from synthesis and self-assembly to cancer treatment
Peptides have shown great potential in cancer treatment due to their good biocompatibility and low toxicity. However, the bioavailability and adverse immune response of peptides limit their further translation from bench to bedside. Over the past few decades, various peptide-based nanomaterials have...
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| Published in | Biomaterials science Vol. 8; no. 22; pp. 6175 - 6189 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
21.11.2020
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Peptides have shown great potential in cancer treatment due to their good biocompatibility and low toxicity. However, the bioavailability and adverse immune response of peptides limit their further translation from bench to bedside. Over the past few decades, various peptide-based nanomaterials have been developed for drug delivery and cancer treatment. Compared with therapeutic peptides alone, self-assembled peptide nanomaterials have obvious advantages, such as improved stability and biodistribution for high-performance cancer therapy. In this review, we have described the synthesis, self-assembly and the anti-cancer application of therapeutic peptides and their conjugates, particularly polymer-peptide conjugates (PPCs).
This review has described the synthesis, self-assembly and the anti-cancer application of therapeutic peptides and their conjugates, particularly polymer-peptide conjugates (PPCs). |
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| Bibliography: | Hao Wang obtained his B.S. and Ph.D. from the Department of Chemistry at Nankai University in 2000 and 2005, respectively. Afterwards, he moved to Universät Würzburg in Germany as an Alexander von Humboldt (AvH) fellow from 2005-2007. Then he worked as a postdoctoral researcher at the Department of Molecular and Medical Pharmacology in UCLA from 2007-2010. Since 2011, he started his independent career in the National Center for Nanoscience and Technology of China. His current research interests are to (i) develop polymeric biomaterials and (ii) study their bio-effect and further regulate their biological behavior; and (iii) explore functional nanomaterials for bioimaging and drug delivery. Ruo-Chen Guo received her B.Eng. from the School of Materials and Chemistry at China Jiliang University in 2017. She is now a Master's candidate in the School of Chemical Engineering and Technology at the Hebei University of Technology under the guidance of Prof. Zhong-Yu Duan. She entered the joint training of National Center for Nanoscience and Technology (NCNST) under the guidance of Prof. Zeng-Ying Qiao and Prof. Hao Wang in 2019. She is currently focusing on (i) design and optimization of self-assembled peptides and (ii) biomedical function of peptide nanomaterials. Zeng-Ying Qiao received her B.S. degree from Shandong University in 2007, majoring in chemistry. She obtained a Ph.D. degree in polymer chemistry and physics from Peking University in 2012. Then she continued her research at the National Center for Nanoscience and Technology as an assistant/associate professor. Since 2019, she has been a professor and her current research interests are studying supramolecular assemblies under physiological conditions, and polymer-peptide nanomaterials and their applications in biomedical areas. Zhong-Yu Duan obtained her Ph.D. from the Department of Chemistry at Nankai University in 2005. Since then she has been working in the Hebei University of Technology. During the period, she moved to the National University of Singapore (August 2007-August 2009) and Dartmouth College in USA (September 2016- September 2017) as a research fellow. Her research interests are to study functional nanomaterials for imaging and drug delivery, supramolecular chemistry and catalytic chemistry. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 2047-4830 2047-4849 2047-4849 |
| DOI: | 10.1039/d0bm01358g |