Evaluation of Oral Glucose Tolerance Test in Children With Epilepsy

Glucose metabolism of children with drug-resistant epilepsy, controlled by antiepileptic drugs epilepsy, and first-time nonfebrile seizures was studied through the performance of an oral glucose tolerance test and through insulin, C-peptide, and glycosylated hemoglobin measurements. In the refractor...

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Bibliographic Details
Published inJournal of child neurology Vol. 28; no. 11; p. 1437
Main Authors Varlamis, Sotirios, Vavatsi, Norma, Pavlou, Evangelos, Kotsis, Vasileios, Spilioti, Martha, Kavga, Maria, Varlamis, George, Sotiriadou, Foteini, Agakidou, Eleni, Voutoufianakis, Spyridon, Evangeliou, Athanasios E
Format Journal Article
LanguageEnglish
Published United States 01.11.2013
Subjects
drug-resistant epilepsy
insulin
glucose tolerance
HbA1c
glucose metabolism
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Summary:Glucose metabolism of children with drug-resistant epilepsy, controlled by antiepileptic drugs epilepsy, and first-time nonfebrile seizures was studied through the performance of an oral glucose tolerance test and through insulin, C-peptide, and glycosylated hemoglobin measurements. In the refractory epilepsy group, there were more abnormal oral glucose tolerance test results (62.07%) in comparison to the controlled epilepsy group (25%) and the group of first-time seizures (21.21%). There was a significant difference between the group of refractory epilepsy and every other group concerning the abnormality of the oral glucose tolerance test (P < .05). The mean values of insulin, HbA , and C-peptide levels were normal for all groups. The results of the present study suggest that there is a distinction of refractory epilepsies from the drug-controlled ones and the first-induced seizures relating to their metabolic profile, regardless of the type of seizures.
ISSN:1708-8283
DOI:10.1177/0883073812460919