Virulent mycobacteria and the many aspects of macrophage uptake

[...]it was found that the melF gene has significant homology to luxA, a monooxygenase with a role in resistance to reactive oxygen intermediates (ROI). Supportive in vitro and in vivo evidence indicates that pathogenic mycobacteria, including M. tuberculosis, M. avium, M. marinum and M. paratubercu...

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Published inFuture microbiology Vol. 2; no. 5; pp. 461 - 464
Main Authors Danelishvili, Lia, Cirillo, Suat LG, Cirillo, Jeffrey D, Bermudez, Luiz E
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.10.2007
Subjects
Animals
Bacteria
Humans
Infection
Leprosy
Macrophages
Macrophages - immunology
Macrophages - microbiology
Macrophages - physiology
Microbiology
Mycobacterium - immunology
Mycobacterium - pathogenicity
Mycobacterium - physiology
Phagocytosis - physiology
Tuberculosis
Virulence
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Summary:[...]it was found that the melF gene has significant homology to luxA, a monooxygenase with a role in resistance to reactive oxygen intermediates (ROI). Supportive in vitro and in vivo evidence indicates that pathogenic mycobacteria, including M. tuberculosis, M. avium, M. marinum and M. paratuberculosis acquire 'invasive'phenotypes when inside of host cells, allowing them to enter secondary cell populations (macrophage, ameba, epithelial cell) with significantly greater efficiency, compared with uptake in the primary infected macrophage.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Commentary-2
content type line 23
ObjectType-Review-1
ObjectType-Editorial-3
ISSN:1746-0913
1746-0921
DOI:10.2217/17460913.2.5.461