Acute effects of glucagon on citrulline biosynthesis

Mitochondria isolated from livers of rats fed on different diets showed altered capacity to synthesize citrulline. Glucagon, 15 min after injection, increases citrulline biosynthesis, except after the high-protein diet. A significant correlation between citrulline biosynthesis and N-acetylglutamate...

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Bibliographic Details
Published inBiochemical journal Vol. 206; no. 3; pp. 627 - 631
Main Authors Rabier, D, Briand, P, Petit, F, Parvy, P, Kamoun, P, Cathelineau, L
Format Journal Article
LanguageEnglish
Published England 15.09.1982
Subjects
Animals
Citrulline - biosynthesis
Dietary Carbohydrates - pharmacology
Dietary Fats - pharmacology
Dietary Proteins - pharmacology
Glucagon - pharmacology
Glutamates - metabolism
Male
Mitochondria, Liver - drug effects
Mitochondria, Liver - metabolism
Rats
Rats, Inbred Strains
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Summary:Mitochondria isolated from livers of rats fed on different diets showed altered capacity to synthesize citrulline. Glucagon, 15 min after injection, increases citrulline biosynthesis, except after the high-protein diet. A significant correlation between citrulline biosynthesis and N-acetylglutamate content with and without glucagon treatment was shown when rats were fed on a standard or a carbohydrate diet. Different diets modified carbamoyl phosphate synthetase I (EC 6.3.4.16) and N-acetylglutamate synthase (acetyl-CoA:L-glutamate N-acetyltransferase, EC 2.3.1.1) activities. Glucagon did not modify these activities.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0264-6021
1470-8728
DOI:10.1042/bj2060627