Novel complex formed by the SAYP transcriptional coactivator

A multisubunit complex that contains the novel evolutionarily conserved transcription factor SAYP was isolated, and its protein composition was determined. SAYP was found to unite two complexes with different functions in transcription activation, namely, the chromatin-remodeling complex PBAP (SWI/S...

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Published inMolecular biology (New York) Vol. 43; no. 6; pp. 982 - 989
Main Authors Soshnikova, N. V, Vorobyeva, N. I, Krasnov, A. N, Georgieva, S. G, Nabirochkina, E. N, Shidlovskii, Yu. V
Format Journal Article
LanguageEnglish
Published Dordrecht Dordrecht : SP MAIK Nauka/Interperiodica 01.12.2009
SP MAIK Nauka/Interperiodica
Springer Nature B.V
Subjects
Biochemistry
Biomedical and Life Sciences
Cell Molecular Biology
Chromatin
Eukaryotes
Genes
Human Genetics
Life Sciences
Molecular biology
Proteins
eukaryotes
promoter
activation of transcription
transcription factors
chromatin-remodeling complexes
chromatin immunoprecipitation
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Summary:A multisubunit complex that contains the novel evolutionarily conserved transcription factor SAYP was isolated, and its protein composition was determined. SAYP was found to unite two complexes with different functions in transcription activation, namely, the chromatin-remodeling complex PBAP (SWI/SNF) and the general transcription factor TFIID, which is the main component of the RNA polymerase II preinitiation complex. The new supercomplex contained the total set of PBAP and TFIID subunits. All components of the supercomplex (SAYP, TFIID, and PBAP) are essential for its effective interaction with the promoters of SAYPdependent genes.
Bibliography:http://dx.doi.org/10.1134/S0026893309060107
ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0026-8933
1608-3245
DOI:10.1134/S0026893309060107