Functions of IgM fc receptor (FcµR) related to autoimmunity

Unlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR gene in mice impairs B cell tolerance as evidenced by concomitant production of autoantibodies of IgM and IgG isotypes. In this essay, we reiter...

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Published inAutoimmunity (Chur, Switzerland) Vol. 57; no. 1; p. 2323563
Main Authors Kubagawa, Hiromi, Mahmoudi Aliabadi, Pedram, Al-Qaisi, Khlowd, Jani, Peter K, Honjo, Kazuhito, Izui, Shozo, Radbruch, Andreas, Melchers, Fritz
Format Journal Article
LanguageEnglish
Published England Taylor & Francis Group 01.12.2024
Subjects
Animals
Autoantibodies
Autoantibody
Autoimmunity
Fc receptor
FCMR deficiency
IgM
Immunoglobulin M
Mice
Receptors, Fc - genetics
tolerance
Autoantibody
FCMR deficiency
Fc receptor
IgM
tolerance
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Summary:Unlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR gene in mice impairs B cell tolerance as evidenced by concomitant production of autoantibodies of IgM and IgG isotypes. In this essay, we reiterate the autoimmune phenotypes observed in mutant mice, ie IgM homeostasis, dysregulated humoral immune responses including autoantibodies, and Mott cell formation. We also propose the potential phenotypes in individuals with deficiency and the model for FcµR-mediated regulation of self-reactive B cells.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0891-6934
1607-842X
DOI:10.1080/08916934.2024.2323563