Functions of IgM fc receptor (FcµR) related to autoimmunity
Unlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR gene in mice impairs B cell tolerance as evidenced by concomitant production of autoantibodies of IgM and IgG isotypes. In this essay, we reiter...
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Published in | Autoimmunity (Chur, Switzerland) Vol. 57; no. 1; p. 2323563 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Taylor & Francis Group
01.12.2024
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Subjects | |
Online Access | Get full text |
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Summary: | Unlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR gene in mice impairs B cell tolerance as evidenced by concomitant production of autoantibodies of IgM and IgG isotypes. In this essay, we reiterate the autoimmune phenotypes observed in mutant mice, ie IgM homeostasis, dysregulated humoral immune responses including autoantibodies, and Mott cell formation. We also propose the potential phenotypes in individuals with
deficiency and the model for FcµR-mediated regulation of self-reactive B cells. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0891-6934 1607-842X |
DOI: | 10.1080/08916934.2024.2323563 |