Naturally occurring prenylated chalcones from plants: structural diversity, distribution, activities and biosynthesis
Covering: up to July 2020 Naturally occurring chalcones carrying up to three modified or unmodified C 5 -, C 10 -, and C 15 -prenyl moieties on both rings A and B as well as at the α- and β-carbons are widely distributed in plants of the families of Fabaceae, Moraceae, Zingiberaceae and Cannabaceae....
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| Published in | Natural product reports Vol. 38; no. 12; pp. 2236 - 226 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
15.12.2021
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Covering: up to July 2020
Naturally occurring chalcones carrying up to three modified or unmodified C
5
-, C
10
-, and C
15
-prenyl moieties on both rings A and B as well as at the α- and β-carbons are widely distributed in plants of the families of Fabaceae, Moraceae, Zingiberaceae and Cannabaceae. Xanthohumol and isobavachalcone being the most investigated representatives, exhibit diverse and remarkable biological and pharmacological activities. The present review deals with their structural characters, biological activities and occurrence in the plant kingdom. Biosynthesis of prenylated chalcones and metabolism of xanthohumol are also discussed.
This review covers the literature until July 2020 on structures, biological activities, distribution and biosynthesis of prenylated chalcones in plants. |
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| Bibliography: | Kang Zhou received her B.Sc. degree in Pharmacy from Hunan University of Traditional Chinese Medicine in 2008; M.Sc. degree under the supervision of Prof. Yuqing Zhao in Medicinal Chemistry of Natural products from Shenyang Pharmaceutical University in 2011; and PhD degree under the supervision of Prof. Shu-Ming Li in Natural Sciences from Institute of Pharmaceutical Biology and Biotechnology of Philipps-University Marburg, Germany, in 2017. She worked as a quality researcher in R&D Center, HEC Pharm Co., Ltd between 2011 and 2013. She joined the School of Pharmaceutical Sciences of Guizhou University in 2018, where she is currently a lecturer of Pharmacy. Her research focuses on chemoenzymatic synthesis of prenylated compounds by prenyltransferases and biosynthesis of secondary metabolites in fungi. Song Yang is a full professor and director at the Key Laboratory of Green Pesticide & Agricultural Bioengineering, Ministry of Education, Centre for R&D of Fine Chemicals of the Guizhou University in Guiyang, China. He received his B.Sc. degree in Chemical Engineering from East China University of Science and Technology in 1995 and received his M.Sc. degree in 2001 and PhD degree in 2005 in Agricultural Pharmacology from Guizhou University. His research lab is interested in organic synthesis methodologies of agricultural chemical and functional molecules. Shu-Ming Li is a full professor of Pharmaceutical Biology and Biotechnology at the Philipps-University in Marburg, Germany. He studied pharmacy and received his Bachelor's and Master's degrees from Beijing University, China. Shu-Ming Li was awarded in 1992 his PhD in natural product chemistry by the Rheinische Friedrich-Wilhelms-University in Bonn, Germany. He has served as an associate professor of Pharmaceutical Biology at the Heinrich-Heine-University in Düsseldorf. Li's group is interested in the biosynthesis of secondary metabolites in bacteria and fungi as well as secondary metabolite enzymes, especially prenyltransferases. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 0265-0568 1460-4752 1460-4752 |
| DOI: | 10.1039/d0np00083c |