A simplified green chemistry approach to the Biginelli reaction using ‘Grindstone Chemistry’

Solvent-free reactions that are complete in a few minutes. Grindstone Chemistry––a greatly evolved version of Toda’s method of grinding solids together for solvent-free chemical reactions––has been described and its usefulness illustrated by the successful application of this technique to a simplifi...

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Bibliographic Details
Published inTetrahedron letters Vol. 45; no. 45; pp. 8351 - 8353
Main Authors Bose, Ajay K., Pednekar, Suhas, Ganguly, Subhendu N., Chakraborty, Goutam, Manhas, Maghar S.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.11.2004
Elsevier
Subjects
Chemistry
Chemistry, Organic
p-TSA as an acid catalyst
Physical Sciences
Reaction by grinding
Science & Technology
Solvent-free reaction
Tetrahydropyrimidinone
Tetrahydropyrimidinone
p-TSA as an acid catalyst
Reaction by grinding
Solvent-free reaction
DIHYDROPYRIMIDINONES
SOLVENT-FREE CONDITIONS
ONE-POT SYNTHESIS
tetrahydropyrimidinone
solvent-free reaction
reaction by grinding
CHLORIDE
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Summary:Solvent-free reactions that are complete in a few minutes. Grindstone Chemistry––a greatly evolved version of Toda’s method of grinding solids together for solvent-free chemical reactions––has been described and its usefulness illustrated by the successful application of this technique to a simplified process for conducting the multi-component Biginelli reaction for the synthesis of physiologically active tetrahydropyrimidinones.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.09.064