Clinical analysis of acute postoperative pain after total laparoscopic hysterectomy for adenomyosis and uterine fibroids - a prospective observational study

• Published in: Annals of medicine (Helsinki) Vol. 55; no. 2; p. 2281510
• Main Authors: Wu, Qing, Zhou, Yun, Sun, Saijun, Li, Hui, Cao, Shanshan, Shou, Huafeng
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Group 2023
• Subjects: Adenomyosis; Adenomyosis - complications; Adenomyosis - surgery; Female; Goserelin - therapeutic use; Humans; Hysterectomy - adverse effects; Laparoscopy - adverse effects; Leiomyoma - etiology; Leiomyoma - surgery; numeric rating scale; Pain, Postoperative - drug therapy; Pain, Postoperative - etiology; total laparoscopic hysterectomy; uterine fibroids; Visceral Pain - etiology; Visceral Pain - surgery; total laparoscopic hysterectomy; numeric rating scale; uterine fibroids; Adenomyosis
• ISSN: 0785-3890; 1365-2060
• DOI: 10.1080/07853890.2023.2281510

To investigate the outcome of total laparoscopic hysterectomy (TLH) and postoperative pain characteristics and compare the pain severity after TLH for adenomyosis or uterine fibroids. This prospective observational study collected 101 patients received TLH for adenomyosis (AD group) including 41 patients were injected goserelin (3.6 mg) 28 days before TLH, while other adenomyosis patients received TLH without preoperative treatment, and 113 patients received TLH for uterine fibroids (UF group). Pain scores were evaluated at different time sites from operation day to postoperative 72 h using the numeric rating scale. Clinical data were collected from clinical record. Operative time and anaesthetic time were longer in the AD group than those in the UF group (66.88 ± 8.65 vs. 64.46 ± 7.21,  = 0.04; 83.95 ± 10.05 vs. 79.77 ± 6.88,  < 0.01), severe endometriosis was quite more common in AD group (23.76% vs. 2.65%,  < 0.01). Postoperative usage of Flurbiprofen in AD group were more than that of UF group (15.48 ± 38.00 vs. 4.79 ± 18.16,  = 0.02). Total pains and abdominal visceral pains of AD group were more severe compared with UF group in motion and rest pattern at several time sites, while incision pain and shoulder pain were similar. The total postoperative pains after goserelin preoperative treatment in AD group were less than that without goserelin preoperative treatment (  < 0.05). The levels of serum NPY, PGE2 and NGF after laparoscopic hysterectomy of adenomyosis reduced with GnRH agonist pretreatment. Acute postoperative pain for adenomyosis and uterine fibroids showed considerably different severity, postoperative total pain and abdominal visceral pains of TLH for adenomyosis were more severe compared with uterine fibroids. While patients received goserelin before laparoscopic hysterectomy of adenomyosis suffered from less severity of postoperative total pain than that without goserelin preoperative treatment.