Multidrug Resistance Plasmid pSK108 from Coagulase-Negative Staphylococci; Relationships to Staphylococcus aureus qacC Plasmids

The 2.4-kb Staphylococcus epidermidis plasmid. pSK108, encodes a qacC multidrug resistance determinant. Sequence analysis has revealed that pSK108 is a member of the pC194 family of rolling circle replicating plasmids and suggests that the DNA segment containing qacC, which is bounded by the replica...

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Bibliographic Details
Published inPlasmid Vol. 34; no. 1; pp. 62 - 67
Main Authors Leelaporn, Amornrut, Firth, Neville, Paulsen, Ian T., Hettiaratchi, Anusha, Skurray, Ronald A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.1995
Subjects
Amino Acid Sequence
Antiporters
Bacterial Proteins - genetics
Base Sequence
Carrier Proteins - genetics
Coagulase - metabolism
DNA, Bacterial - genetics
Drug Resistance, Multiple - genetics
Escherichia coli Proteins
Genes, Bacterial
Membrane Proteins - genetics
Molecular Sequence Data
Plasmids - genetics
Staphylococcus
Staphylococcus aureus - genetics
Staphylococcus epidermidis - drug effects
Staphylococcus epidermidis - enzymology
Staphylococcus epidermidis - genetics
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Summary:The 2.4-kb Staphylococcus epidermidis plasmid. pSK108, encodes a qacC multidrug resistance determinant. Sequence analysis has revealed that pSK108 is a member of the pC194 family of rolling circle replicating plasmids and suggests that the DNA segment containing qacC, which is bounded by the replication nick site and the minus origin palA, represents a resistance gene cassette that has undergone horizontal genetic exchange.
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ISSN:0147-619X
1095-9890
DOI:10.1006/plas.1995.1034