Alkaloids and Flavonoids of Aerial Parts of Ipomea pes-tigridis (Convolvulaceae) are Potential Inhibitors of Staphylococcus epidermidis and Propionibacterium acnes

• Published in: Journal of herbs, spices & medicinal plants Vol. 18; no. 4; pp. 370 - 386
• Main Authors: Sandhya, S, Sravanthi, E. Vidya, Vinod, K. R, Gouthami, G, Saikiran, M, Banji, David
• Format: Journal Article
• Language: English
• Published: Binghamton, NY Taylor & Francis Group 01.11.2012; Haworth Press; Taylor & Francis Ltd
• Subjects: Acne; aerial parts; Alkaloids; anti-inflammatory activity; antibacterial properties; Antiinflammatory agents; Antimicrobial agents; Bacteria; bioautography; Biological and medical sciences; Carrageenan; Chromatography; Convolvulaceae; Flavonoids; Flowers & plants; Fundamental and applied biological sciences. Psychology; Herbal medicines; Medicinal plants; Metabolites; Minimum inhibitory concentration; Phytochemicals; Propionibacterium acnes; screening; Spices; Staphylococcus epidermidis; Convolvulaceae; Flavonoid; Alkaloid; Ipomoea; Staphylococcus epidermidis; Dicotyledones; Pathogenic; Angiospermae; Propionibacteriaceae; Bacteria; Micrococcales; Actinomycetes; Micrococcaceae; Spermatophyta; Inhibitor; Carrageenan; Propionibacterium acnes; bioautography
• ISSN: 1540-3580; 1049-6475; 1540-3580
• DOI: 10.1080/10496475.2012.715118

Aerial parts of Ipomea pes-tigridis were extracted by soxhlet extraction and then subjected to preliminary phytochemical screening. Results exposed similar kind of phytochemicals in the methanolic extract of all the parts. This was further confirmed by thin layer chromatographic analysis. Hence the extracts were pooled and screened for anti-bacterial activity against routine bacterial strains and then the anti acne activity against Staphylococcus epidermidis and Propionibacterium acnes. It was observed that S. epidermidis was more susceptible to the extract than P. acnes as the minimum inhibitory concentration was determined to be 96 μg.mL⁻¹ and 100 μg.mL⁻¹ respectively. Bioautography performed revealed that alkaloids and flavonoids were the potent inhibitors of these micro organisms. The anti-inflammatory activity was screened showed that 100 mg.kg⁻¹ as the most effective dose.