Cerebrospinal fluid creatine kinase activity in horses with central nervous system disease: 69 cases (1984-1989)

• Published in: Journal of the American Veterinary Medical Association Vol. 197; no. 2; p. 245
• Main Authors: Furr, M.O. (Virginia, Maryland Regional College of Veterinary Medicine, Blacksburg, VA), Tyler, R.D
• Format: Journal Article
• Language: English
• Published: United States 15.07.1990
• Subjects: ACTIVIDAD ENZIMATICA; ACTIVITE ENZYMATIQUE; Animals; CABALLOS; CENTRAL NERVOUS SYSTEM; Central Nervous System Diseases - cerebrospinal fluid; Central Nervous System Diseases - veterinary; CEREBROSPINAL FLUID; CHEVAL; Creatine Kinase - cerebrospinal fluid; ENZYMIC ACTIVITY; FLUIDO CEREBROESPINAL; Horse Diseases - cerebrospinal fluid; HORSES; LIQUIDE CEPHALORACHIDIEN; NERVOUS SYSTEM DISEASES; Retrospective Studies; SISTEMA NERVIOSO CENTRAL; SYSTEME NERVEUX CENTRAL; TRANSFERASAS; TRANSFERASE; TRANSFERASES; TRASTORNOS DEL SISTEMA NERVIOSO; TROUBLE DU SYSTEME NERVEUX
• ISSN: 0003-1488; 1943-569X
• DOI: 10.2460/javma.1990.197.02.245

The CSF creatine kinase (CK) activity was determined in 70 CSF samples from 69 horses with CNS disease. Abnormal values (greater than or equal to 1 IU/L) were determined from 32 CSF samples, and normal values (less than 1 IU/L) were found in 38 samples. Increased CK activity was most frequently associated with a diagnosis of equine protozoal myelitis; CK activity was not increased in 11 horses with cervical compressive myelopathy. Other diagnoses, in which CSF CK activity was increased included trauma (n = 1), idiopathic epilepsy (n = 2), botulism (n = 2), articular facet fracture (n = 1), intervertebral disk protrusion (n = 1), and toxemia (n = 1).