Increased transcription and decreased degradation control and recovery of liver ribosomes after a period of protein starvation

In the livers of 5-days-protein-depleted mice there is a decrease of 47% of the ribosome mass. When these animals are fed with an adequate diet, ribosome content is restored to the normal value after 1 day of re-feeding. The mechanisms underlying this phenomenon were studied. It was found that: (1)...

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Bibliographic Details
Published inBiochemical journal Vol. 192; no. 3; pp. 935 - 940
Main Authors Conde, R D, Franze-Fernández, M T
Format Journal Article
LanguageEnglish
Published England 15.12.1980
Subjects
Animals
Dietary Proteins
DNA - metabolism
Kinetics
Liver - metabolism
Male
Mice
Protein Deficiency - metabolism
Ribosomes - metabolism
RNA Polymerase I - metabolism
RNA, Ribosomal - metabolism
Transcription, Genetic
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Summary:In the livers of 5-days-protein-depleted mice there is a decrease of 47% of the ribosome mass. When these animals are fed with an adequate diet, ribosome content is restored to the normal value after 1 day of re-feeding. The mechanisms underlying this phenomenon were studied. It was found that: (1) the activity of RNA polymerase I in the nuclei of livers from re-fed animals showed an enhancement of about 2-fold compared with the activity in normal and protein-depleted liver nuclei; (2) ribosome degradation, measured by the disappearance of radioactivity from ribosomal proteins previously labelled by the administration of NaH14CO3 to the mice, stopped during the first day after re-feeding.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0264-6021
1470-8728
DOI:10.1042/bj1920935