Copper-catalyzed tandem reaction between imines and alcohols leading to indoles
Graphic A copper-catalyzed tandem reaction between 2-alkynyl- N-arylideneanilines and alcohols is found to produce N-(alkoxybenzyl)indoles in good to high yields. A wide variety of substituted N-(alkoxybenzyl)indole derivatives can be synthesized by utilizing this protocol, since the derived indoles...
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Published in | Tetrahedron letters Vol. 45; no. 1; pp. 35 - 38 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
2004
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Graphic
A copper-catalyzed tandem reaction between 2-alkynyl-
N-arylideneanilines and alcohols is found to produce
N-(alkoxybenzyl)indoles in good to high yields. A wide variety of substituted
N-(alkoxybenzyl)indole derivatives can be synthesized by utilizing this protocol, since the derived indoles are essentially formed by the four-component assemblies of aldehydes, 2-iodoanilines, terminal alkynes, and alcohols. |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/j.tetlet.2003.10.141 |