The Biological Activity of 6-Chloro-7-Methyl-9-(1′-D-Ribityl)-Isoalloxazine

1.It has been found that 6-chloro-7-methyl-9-(1′-D-ribityl)-isoalloxazine is a reversible antagonist of riboflavin in the nutrition of Lactobacillus casei with an inhibition index of 76.2.This analog of riboflavin has also been found to be a reversible antagonist in the nutrition of the rat. The gro...

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Bibliographic Details
Published inThe Journal of nutrition Vol. 72; no. 2; pp. 169 - 176
Main Authors Haley, E.E., Lambooy, J.P.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.1960
Subjects
Flavins
Old Medline
Riboflavin - antagonists & inhibitors
VITAMIN B 2/antagonists
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Summary:1.It has been found that 6-chloro-7-methyl-9-(1′-D-ribityl)-isoalloxazine is a reversible antagonist of riboflavin in the nutrition of Lactobacillus casei with an inhibition index of 76.2.This analog of riboflavin has also been found to be a reversible antagonist in the nutrition of the rat. The growth which is stimulated by low levels of this material is approximately equal to the growth stimulated by one-half the quantity of riboflavin. High levels of the analog are lethal to the animal if adequate amounts of riboflavin are not available.
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ISSN:0022-3166
DOI:10.1093/jn/72.2.169