A self-powered 3D DNA walker with programmability and signal-amplification for illuminating microRNA in living cells

Based on the structural programmability and spatial addressability of DNA nanodevices, a target-triggered, enzyme-free 3D DNA walker, comprising of hairpin DNA assembled gold nanoparticles with a local catalytic hairpin assembly reaction, was developed for the highly sensitive detection of intracell...

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Published inChemical communications (Cambridge, England) Vol. 56; no. 14; pp. 2135 - 2138
Main Authors Yang, Xue-Jiao, Cui, Mei-Rong, Li, Xiang-Ling, Chen, Hong-Yuan, Xu, Jing-Juan
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 18.02.2020
Subjects
catalytic activity
Cell Line, Tumor
chemical compounds
chemical reactions
Deoxyribonucleic acid
DNA
DNA - chemistry
Gold - chemistry
HEK293 Cells
Humans
Metal Nanoparticles - chemistry
microRNA
MicroRNAs
MicroRNAs - chemistry
nanogold
Nanoparticles
Nanotechnology devices
Nucleic Acid Amplification Techniques
Ribonucleic acid
RNA
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Summary:Based on the structural programmability and spatial addressability of DNA nanodevices, a target-triggered, enzyme-free 3D DNA walker, comprising of hairpin DNA assembled gold nanoparticles with a local catalytic hairpin assembly reaction, was developed for the highly sensitive detection of intracellular tumor-associated microRNAs. We construct a target-triggered, self-powered 3D DNA walker for achieving intracellular signal amplification and sensitive imaging analysis of microRNAs.
Bibliography:10.1039/c9cc09039h
Electronic supplementary information (ESI) available. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c9cc09039h