Hijacking host cell vesicular transport: New insights into the nutrient acquisition mechanism of Chlamydia

• Published in: Virulence Vol. 15; no. 1; p. 2351234
• Main Authors: Wenbo, Lei, Yewei, Yang, Hui, Zhou, Zhongyu, Li
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis Group 01.12.2024
• Subjects: Animals; Biological Transport; Chlamydia; Chlamydia - metabolism; Chlamydia - pathogenicity; Chlamydia - physiology; Chlamydia Infections - metabolism; Chlamydia Infections - microbiology; Host-Pathogen Interactions; Humans; nutrient acquisition; Nutrients - metabolism; Rab GTPases; vesicular transport; Chlamydia; Rab GTPases; nutrient acquisition; vesicular transport
• ISSN: 2150-5594; 2150-5608
• DOI: 10.1080/21505594.2024.2351234

infection is an important cause of public health diseases, and no effective vaccine is currently available. Owing to its unique intracellular lifestyle, requires a variety of nutrients and substrates from host cells, particularly sphingomyelin, cholesterol, iron, amino acids, and the mannose-6-phosphate receptor, which are essential for inclusion development. Here, we summarize the recent advances in nutrient acquisition mechanism by hijacking host cell vesicular transport, which plays an important role in chlamydial growth and development. obtains the components necessary to complete its intracellular developmental cycle by recruiting Rab proteins (major vesicular trafficking regulators) and Rab effector proteins to the inclusion, interfering with Rab-mediated multivesicular trafficking, reorienting the nutrition of host cells, and reconstructing the intracellular niche environment. Consequently, exploring the role of vesicular transport in nutrient acquisition offers a novel perspective on new approaches for preventing and treating infection.