In vivo testing of a completely implanted total artificial heart system

The authors performed 14 implants of a completely implanted total artificial heart (TAH) system in calves. The system consisted of a dual pusher plate rollerscrew energy converter, two sac type blood pumps, an implanted electronic control and battery package, and a transcutaneous energy transmission...

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Bibliographic Details
Published inASAIO journal (1992) Vol. 39; no. 3; p. M177
Main Authors Snyder, A J, Rosenberg, G, Weiss, W J, Ford, S K, Nazarian, R A, Hicks, D L, Marlotte, J A, Kawaguchi, O, Prophet, G A, Sapirstein, J S
Format Journal Article
LanguageEnglish
Published United States 01.07.1993
Subjects
Animals
Blood Urea Nitrogen
Cardiac Output - physiology
Cattle
Creatinine - blood
Electric Power Supplies
Heart, Artificial
Hemolysis - physiology
Liver Function Tests
Prosthesis Design
Prosthesis Failure
Signal Processing, Computer-Assisted - instrumentation
Telemetry - instrumentation
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Summary:The authors performed 14 implants of a completely implanted total artificial heart (TAH) system in calves. The system consisted of a dual pusher plate rollerscrew energy converter, two sac type blood pumps, an implanted electronic control and battery package, and a transcutaneous energy transmission system. Ten of the implants included a percutaneous lead for monitoring of the implant; the remainder made use of wireless two way telemetry between the implant and the outside. Three animals survived the perioperative period. These calves survived for 98 to 118 days, and one was still alive at 150 days. Causes for termination of the 98 and 118 day cases were abdominal pocket sepsis originating at a monitoring line, and systemic sepsis acquired perioperatively. Death or termination in the shorter cases was mainly due to respiratory complications or bleeding. The TAH system proved capable of providing adequate cardiac outputs at modest atrial pressures. Wireless monitoring and wireless intervention for weaning from cardiopulmonary bypass were readily achieved. All organ systems functioned normally in the presence of the device. Once recovery from implantation in these very young animals was achieved, the system proved its ability to reliably support these animals until body mass exceeded its cardiac output capabilities.
ISSN:1058-2916
DOI:10.1097/00002480-199307000-00006