Polyamines stimulate suppression of amber termination codons in vitro by normal tRNAs [wheat germ]

• Published in: European journal of biochemistry Vol. 105; no. 3; pp. 445 - 451
• Main Authors: Morch, M.-D, Benicourt, C. (Paris Univ. (France). Inst. de Recherche en Biologie Moleculaire. Lab. de Biochimie du Developpement)
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.1980
• Subjects: Animals; Codon - metabolism; Electrophoresis, Polyacrylamide Gel; Plant Viruses - metabolism; Rabbits; Rats; RNA, Messenger - metabolism; RNA, Transfer - metabolism; RNA, Viral - metabolism; Sodium Dodecyl Sulfate; Spermidine - pharmacology; Spermine - pharmacology; Stimulation, Chemical

Polyamines, such as spermine and spermidine, are able to stimulate reading of amber termination codons on viral messenger RNAs in vitro. This phenomenon is not due to an overall increase of error frequency during translation, but to a specific effect on a normal tRNA that is present in various eukar...