Polyamines stimulate suppression of amber termination codons in vitro by normal tRNAs [wheat germ]

Polyamines, such as spermine and spermidine, are able to stimulate reading of amber termination codons on viral messenger RNAs in vitro. This phenomenon is not due to an overall increase of error frequency during translation, but to a specific effect on a normal tRNA that is present in various eukar...

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Published inEuropean journal of biochemistry Vol. 105; no. 3; pp. 445 - 451
Main Authors Morch, M.-D, Benicourt, C. (Paris Univ. (France). Inst. de Recherche en Biologie Moleculaire. Lab. de Biochimie du Developpement)
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.04.1980
Subjects
Animals
Codon - metabolism
Electrophoresis, Polyacrylamide Gel
Plant Viruses - metabolism
Rabbits
Rats
RNA, Messenger - metabolism
RNA, Transfer - metabolism
RNA, Viral - metabolism
Sodium Dodecyl Sulfate
Spermidine - pharmacology
Spermine - pharmacology
Stimulation, Chemical
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Summary:Polyamines, such as spermine and spermidine, are able to stimulate reading of amber termination codons on viral messenger RNAs in vitro. This phenomenon is not due to an overall increase of error frequency during translation, but to a specific effect on a normal tRNA that is present in various eukaryotic cell preparations. The enhancement of reading of termination codons by normal tRNAs should be of major importance for the expression of specific genes in eukaryotic cells.
Bibliography:F60
804Y035
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0014-2956
1432-1033
DOI:10.1111/j.1432-1033.1980.tb04519.x