PCV3 in Thailand: Molecular epidemiology and relationship with PCV2

• Published in: Transboundary and emerging diseases Vol. 68; no. 6; pp. 2980 - 2989
• Main Authors: Visuthsak, Wansika, Woonwong, Yonlayong, Thanantong, Narut, Poolperm, Pariwat, Boonsoongnern, Alongkot, Ratanavanichrojn, Nattavut, Jirawattanapong, Pichai, Soda, Nantana, Kaminsonsakul, Tanyanant, Phuttapatimok, Sahathat, Sukmak, Manakorn
• Format: Journal Article
• Language: English
• Published: Berlin Hindawi Limited 01.11.2021
• Subjects: Epidemiology; molecular epidemiology; Pathogenesis; PCV3; PCVAD; Reproductive failure; Sequence analysis; Swine; Thailand; Viruses; Thailand
• ISSN: 1865-1674; 1865-1682
• DOI: 10.1111/tbed.14294

Porcine circovirus type 3 has been circulating throughout the world and since their first report, various clinical signs and disease developments have been documented. The virus is similar to the closely related PCV2 and is associated with several clinical signs called porcine circovirus‐associated diseases (PCVAD). PCV2 or PCV3 is occasionally reported with clinical signs such as PDNS, respiratory signs and reproductive failure. Retrospective research conducted in Thailand revealed that both PCV2 and PCV3 have been circulation for decades. However, awareness about PCV3 infection has just arisen in recent years because of the similarities observed in disease circulation and clinical signs that have led to concerns. This study was conducted to find the relationship between the quantity of PCV2 and PCV3 in Thai pigs displaying the clinical signs related to PCVAD. A total of 479 serum samples with different production phases and clinical signs were sent to Kamphaeng Saen Veterinary Diagnostic Center (KVDC) for qPCR to detect the presence of PCV2 or PCV3. There was no relationship between the PCV3 and PCVAD‐related clinical signs. Also, the relationship between PCV2 and PCV3 with no clinical signs suggested that both viruses might come from the same reservoir or have been circulating in Thailand for a long time, leading to common incidents in finding. The viral load of PCV2 was significantly different among the pig groups with and without clinical signs. The capsid sequence analysis of PCV3 revealed that 22 capsid sequences obtained from this study were found as clusters within PCV3a with a minor variation. Additional control measures are further needed to reduce the findings of the viruses. A future study with a control experiment may be needed to clarify the pathogenesis of PCV3.