The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases

• Published in: Frontiers in bioscience Vol. 13; no. 13; pp. 3046 - 3082
• Main Authors: Hassa, Paul O, Hottiger, Michael O
• Format: Journal Article
• Language: English
• Published: United States 01.01.2008
• Subjects: Adenosine Diphosphate - chemistry; Animals; Cell Death; Chromatin - chemistry; Chromatin Immunoprecipitation; Crystallization; Humans; Mass Spectrometry - methods; Mice; Mice, Transgenic; Multigene Family; Poly(ADP-ribose) Polymerases - chemistry; Poly(ADP-ribose) Polymerases - physiology; Protein Binding; Protein Isoforms; Ribose - chemistry

Poly-ADP-ribose metabolism plays a mayor role in a wide range of biological processes, such as maintenance of genomic stability, transcriptional regulation, energy metabolism and cell death. Poly-ADP-ribose polymerases (PARPs) are an ancient family of enzymes, as evidenced by the poly-ADP-ribosylati...