Serotonin receptors: guardians of stable breathing

Disturbances of breathing arising from failures of the respiratory center are not uncommon. Among them, breath holding and apnea occur most frequently as consequences of pulmonary and cardiac diseases, hypoxia, head trauma, cerebral inflammatory processes, genetic defects, degenerative brain disease...

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Published inTrends in molecular medicine Vol. 9; no. 12; pp. 542 - 548
Main Authors Richter, Diethelm W, Manzke, Till, Wilken, Bernd, Ponimaskin, Evgeni
Format Journal Article
LanguageEnglish
Published England 01.12.2003
Subjects
Animals
Brain - pathology
Humans
Models, Biological
Receptors, Serotonin - metabolism
Receptors, Serotonin - physiology
Respiration
Respiration Disorders - pathology
Serotonin - metabolism
Signal Transduction
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Summary:Disturbances of breathing arising from failures of the respiratory center are not uncommon. Among them, breath holding and apnea occur most frequently as consequences of pulmonary and cardiac diseases, hypoxia, head trauma, cerebral inflammatory processes, genetic defects, degenerative brain diseases, alcoholism, deep anesthesia and drug overdose. They are often life-threatening and fail to respond to existing pharmacotherapies. After extensive research, there is now a reliable basis for new strategies to treat respiratory disturbances by pharmacological manipulation of intracellular signaling pathways, particularly those involving the serotonin receptor family. Specific activation of these pathways effectively prevails respiratory disturbances and can be extended to treatment of life-threatening respiratory disorders in patients.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2003.10.010