A novel amphiphilic pH-sensitive hydrogel based on pullulan

Novel polyelectrolyte and amphiphilic hydrogels based on pullulan have been prepared using 1-ethyl-3-[3-(dimethylamino)-propyl]carbodiimide hydrochloride and N-hydroxysuccinimide. The cross-linking reaction is fast and lead to zero length ester cross-links by the reaction of a carboxylate group with...

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Bibliographic Details
Published inColloid and polymer science Vol. 285; no. 10; pp. 1085 - 1091
Main Authors DULONG, Virginie, MOCANU, Georgeta, LE CERF, Didier
Format Journal Article
LanguageEnglish
Published Berlin Springer 01.07.2007
Springer Nature B.V
Springer Verlag
Subjects
Applied sciences
Chemical Sciences
Chemical-mechanical polishing
Crosslinking
Esters
Exact sciences and technology
Grafting
Hydrogels
Material chemistry
Natural polymers
Physicochemistry of polymers
Polyelectrolytes
Polymers
Pullulan
Starch and polysaccharides
Structure effect
Pullulan
Swelling
Crosslinking
Pullulan derivative
Experimental study
Esterification
Colloidal gel
Polyelectrolyte
Chemical modification
Ionic strength
Preparation
Carboxymethylation
pH
pH sensitive
Oside polymer
Amphiphile
Polyacid
Kinetics
Hydrogel
Amphiphilic polymer
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Summary:Novel polyelectrolyte and amphiphilic hydrogels based on pullulan have been prepared using 1-ethyl-3-[3-(dimethylamino)-propyl]carbodiimide hydrochloride and N-hydroxysuccinimide. The cross-linking reaction is fast and lead to zero length ester cross-links by the reaction of a carboxylate group with an alcohol function of the polysaccharide. The charge density and the hydrophobic rate of the precursor carboxymethylpullulan (CMP) are controlled during the carboxymethylation of pullulan and the grafting reaction of octyl chains on CMP, respectively. The grafting degree influences the conformation of the hydrophobically modified CMP (HMCMP) in solution and leads to the formation of hydrophobic clusters firstly in the HMCMP solutions and further in the HMCMP hydrogels. The swelling measurements of HMCMP hydrogels at different salt concentrations (0-0.2 M NaCl) and different pH (3-11) shows the ionic strength and pH sensitivity of the gels. The loading of a hydrophobic probe molecule can be controlled by the grafting degree of HMCMP hydrogels.[PUBLICATION ABSTRACT]
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0303-402X
1435-1536
DOI:10.1007/s00396-007-1655-3