Antibody Arrays in Cancer Research

Antibody arrays have valuable applications in cancer research. Many different antibody array technologies have been developed, each with particular advantages, disadvantages, and optimal applications. The methods have been demonstrated on various sample types, such as serum, plasma, and other bodily...

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Published inMolecular & cellular proteomics Vol. 4; no. 4; pp. 377 - 383
Main Author Haab, Brian B
Format Journal Article
LanguageEnglish
Published United States American Society for Biochemistry and Molecular Biology 01.04.2005
Subjects
Animals
Antibodies, Neoplasm - immunology
Humans
Neoplasms - immunology
Neoplasms, Experimental - immunology
Protein Array Analysis
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Abstract Antibody arrays have valuable applications in cancer research. Many different antibody array technologies have been developed, each with particular advantages, disadvantages, and optimal applications. The methods have been demonstrated on various sample types, such as serum, plasma, and other bodily fluids; cell culture supernatants; tissue culture lysates; and resected tumor specimens. The applications to cancer research have included profiling proteins to identify candidate biomarkers, characterizing signaling pathways, and the measurement of changes in modification or expression level of cancer-related proteins. Further innovations in the methods and experimental strategies are broadening the scope of the applications and the type of information that can be gathered. These alternate formats and uses of antibody arrays include arrays to measure whole cells, arrays to measure enzyme activities, reverse phase arrays, and bead-based arrays. This article reviews the various types of antibody array methods and their applications to cancer research.
AbstractList Antibody arrays have valuable applications in cancer research. Many different antibody array technologies have been developed, each with particular advantages, disadvantages, and optimal applications. The methods have been demonstrated on various sample types, such as serum, plasma, and other bodily fluids; cell culture supernatants; tissue culture lysates; and resected tumor specimens. The applications to cancer research have included profiling proteins to identify candidate biomarkers, characterizing signaling pathways, and the measurement of changes in modification or expression level of cancer-related proteins. Further innovations in the methods and experimental strategies are broadening the scope of the applications and the type of information that can be gathered. These alternate formats and uses of antibody arrays include arrays to measure whole cells, arrays to measure enzyme activities, reverse phase arrays, and bead-based arrays. This article reviews the various types of antibody array methods and their applications to cancer research.
Antibody arrays have valuable applications in cancer research. Many different antibody array technologies have been developed, each with particular advantages, disadvantages, and optimal applications. The methods have been demonstrated on various sample types, such as serum, plasma, and other bodily fluids; cell culture supernatants; tissue culture lysates; and resected tumor specimens. The applications to cancer research have included profiling proteins to identify candidate biomarkers, characterizing signaling pathways, and the measurement of changes in modification or expression level of cancer-related proteins. Further innovations in the methods and experimental strategies are broadening the scope of the applications and the type of information that can be gathered. These alternate formats and uses of antibody arrays include arrays to measure whole cells, arrays to measure enzyme activities, reverse phase arrays, and bead-based arrays. This article reviews the various types of antibody array methods and their applications to cancer research.
Author Brian B. Haab
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/15671041$$D View this record in MEDLINE/PubMed
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Snippet Antibody arrays have valuable applications in cancer research. Many different antibody array technologies have been developed, each with particular advantages,...
Antibody arrays have valuable applications in cancer research. Many different antibody array technologies have been developed, each with particular advantages,...
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SubjectTerms Animals
Antibodies, Neoplasm - immunology
Humans
Neoplasms - immunology
Neoplasms, Experimental - immunology
Protein Array Analysis
Title Antibody Arrays in Cancer Research
URI http://www.mcponline.org/content/4/4/377.abstract
https://www.ncbi.nlm.nih.gov/pubmed/15671041
https://search.proquest.com/docview/67553208
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