Antibody Arrays in Cancer Research
Antibody arrays have valuable applications in cancer research. Many different antibody array technologies have been developed, each with particular advantages, disadvantages, and optimal applications. The methods have been demonstrated on various sample types, such as serum, plasma, and other bodily...
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Published in | Molecular & cellular proteomics Vol. 4; no. 4; pp. 377 - 383 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
United States
American Society for Biochemistry and Molecular Biology
01.04.2005
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Subjects | |
Online Access | Get full text |
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Summary: | Antibody arrays have valuable applications in cancer research. Many different antibody array technologies have been developed,
each with particular advantages, disadvantages, and optimal applications. The methods have been demonstrated on various sample
types, such as serum, plasma, and other bodily fluids; cell culture supernatants; tissue culture lysates; and resected tumor
specimens. The applications to cancer research have included profiling proteins to identify candidate biomarkers, characterizing
signaling pathways, and the measurement of changes in modification or expression level of cancer-related proteins. Further
innovations in the methods and experimental strategies are broadening the scope of the applications and the type of information
that can be gathered. These alternate formats and uses of antibody arrays include arrays to measure whole cells, arrays to
measure enzyme activities, reverse phase arrays, and bead-based arrays. This article reviews the various types of antibody
array methods and their applications to cancer research. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 1535-9476 1535-9484 |
DOI: | 10.1074/mcp.M500010-MCP200 |