AIDS-related lymphoma

The incidence of intermediate and high grade B-cell non-Hodgkin’s lymphomas in HIV-infected individuals is approximately 60 times greater than in the general population. These AIDS-related lymphomas (AIDS-NHL) are a late manifestation of HIV infection and may increase in frequency as patients live l...

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Bibliographic Details
Published inBlood reviews Vol. 13; no. 3; pp. 147 - 150
Main Authors Tulpule, A., Levine, A.
Format Journal Article
LanguageEnglish
Published Kent Elsevier Ltd 01.09.1999
Elsevier
Subjects
AIDS/HIV
Biological and medical sciences
Human viral diseases
Humans
Incidence
Infectious diseases
Lymphoma, AIDS-Related - epidemiology
Lymphoma, AIDS-Related - etiology
Lymphoma, AIDS-Related - therapy
Medical sciences
Prognosis
Viral diseases
Viral hepatitis
Human
Immunopathology
AIDS
Malignant hemopathy
B-Lymphocyte
Review
Non Hodgkin lymphoma
Immune deficiency
Epidemiology
Infection
Association
Lymphoproliferative syndrome
Viral disease
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Summary:The incidence of intermediate and high grade B-cell non-Hodgkin’s lymphomas in HIV-infected individuals is approximately 60 times greater than in the general population. These AIDS-related lymphomas (AIDS-NHL) are a late manifestation of HIV infection and may increase in frequency as patients live longer with highly active antiretroviral therapy and effective prophylaxis of opportunistic infections. AIDS-NHL have unique clinical and pathological features that are different from non-Hodgkin’s lymphomas in the general population. Histologically AIDS-NHL are either high (2/3) or intermediate (1/3) grade lymphomas. Clinically AIDS-NHL have a preponderance for extranodal involvement with central nervous system being the most common site for this. In addition to the clinical and pathological features of AIDS-NHL, a current knowledge of their pathogenesis and treatment options are presented in this review.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0268-960X
1532-1681
DOI:10.1054/blre.1999.0112