Beneficial effects of probiotic supplementation on glucose and triglycerides in a mouse model of metabolic syndrome

• Published in: Journal of functional foods Vol. 95; p. 105167
• Main Authors: Zavišić, Gordana, Ristić, Slavica, Rikalović, Milena, Petković, Branka, Janković, Drina, Vukadinović, Aleksandar, Petričević, Saša
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.08.2022; Elsevier
• Subjects: Biochemical parameters; Lactobacillus spp; Metabolic syndrome; Metabolic syndrome; Lactobacillus spp; Biochemical parameters
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2022.105167

[Display omitted] •Metabolic syndrome is a cluster of metabolic disorders that occur together.•High-fat high-sucrose-fed mouse is a widely used rodent model of metabolic syndrome.•High-fat high-sucrose diet increases glucose, triglycerides, and body weight.•Lactobacillus supplementation alleviates high-fat high-sucrose diet-induced changes. The present study aimed to examine the effect of Lactobacillus rhamnosus Rosell 11 and Lactobacillus helveticus Rosell 52 on glucose (blood level and tolerance), lipids (cholesterol and triglycerides), transaminases (AST and ALT), ALP, urea, and creatinine, along with body weight, food intake, liquid consumption, and gross pathology in a mouse model of metabolic syndrome. Male C57BL/6J mice were fed a high-fat high-sucrose diet and treated by oral gavage with a probiotic mixture in three different concentrations (107, 108, and 109 CFU/mL) once daily for 2 months. Probiotic supplementation, particularly at a concentration of 109 CFU, significantly decreased blood glucose and serum triglyceride levels, improved glucose tolerance, and promoted body weight loss in mice fed a high-fat high-sucrose diet. According to the obtained results, probiotic supplementation is useful for controlling glucose and triglyceride levels and could be used as an adjunctive therapeutic approach in patients with metabolic syndrome.