Lymphocyte adherence to myelinated tissue in multiple sclerosis

A small subpopulation of human peripheral blood T lymphocytes has the capacity to adhere selectively to myelinated sections of human and nonhuman brain tissue. Adherence of lymphocytes from patients with multiple sclerosis is significantly greater than adherence of control lymphocytes. Monocytes inh...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of clinical investigation Vol. 66; no. 4; pp. 843 - 846
Main Authors Dore-Duffy, P, Goertz, V, Rothman, B L
Format Journal Article
LanguageEnglish
Published United States 01.10.1980
Subjects
Cell Adhesion
Female
Humans
Male
Monocytes - immunology
Multiple Sclerosis - immunology
Nerve Fibers, Myelinated - immunology
T-Lymphocytes - immunology
Online AccessGet full text

Cover

More Information
Summary:A small subpopulation of human peripheral blood T lymphocytes has the capacity to adhere selectively to myelinated sections of human and nonhuman brain tissue. Adherence of lymphocytes from patients with multiple sclerosis is significantly greater than adherence of control lymphocytes. Monocytes inhibit binding in controls. This function appears to be lost by multiple sclerosis monocytes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-9738
DOI:10.1172/JCI109922