The roles of platelet function, thromboxane, blood lipids and nitric oxide in hypertension of children and adolescents

• Published in: Prostaglandins, leukotrienes and essential fatty acids Vol. 62; no. 5; pp. 293 - 297
• Main Authors: Bereczki, Cs, Túr, S., Németh, I., Sallai, É., Torday, Cs, Nagy, E., Haszon, I., Papp, F.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.05.2000; Elsevier
• Subjects: Adolescent; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure; Cardiology. Vascular system; Child; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Cyclic AMP - blood; Dialysis; Female; Humans; Hyperlipidemias - complications; Hyperlipidemias - physiopathology; Hypertension - blood; Hypertension - etiology; Lipids - blood; Lipids - physiology; Lipoproteins - blood; Male; Medical sciences; Nitric Oxide - blood; Nitric Oxide - physiology; Platelet Aggregation - physiology; Renal Insufficiency - blood; Thromboxane B2 - blood; Thromboxane B2 - physiology; Human; Hypertension; Platelet; Arachidonic acid derivatives; Eicosanoid; Nitric oxide; Adolescent; Cardiovascular disease; Thromboxane; Child
• ISSN: 0952-3278; 1532-2823
• DOI: 10.1054/plef.2000.0157

The roles of platelet function, plasma lipids and nitric oxide (NO) were studied in adolescent patients with essential hypertension (JEHT group), with chronic renal failure (CRF) associated with hypertension (CRFH group), and CRF patients with normal blood pressure (CRF group), as compared with normal controls (cont. group). Platelet aggregation and the thromboxane B2(TxB2) level were significantly higher in the JEHT and CRFH groups as compared with the cont. group, whereas they were significantly lower in the CRF group. On the other hand, the platelet cAMP level was significantly lower in the JEHT and CRFH groups than in the cont. group. The plasma NO level was significantly higher only in the JEHT as compared with the cont. group (120 ± 39 and 89 ± 21 μM, respectively). The plasma total cholesterol, triglyceride and LDL cholesterol concentrations were normal in the JEHT group, but high in the CRF and CRFH group, the HDL cholesterol level was lower in the CRF and CRFH groups as compared with the cont. and JEHT groups. There was a positive correlation between the platelet aggregation and the TxB2level and between the BP and the platelet aggregation. In conclusion, hyperlipidaemia is commonly present in uraemia with haemodialysis, but is not specific for hypertension in children, while an increased platelet function is frequently associated with hypertension. The increased NO level might play a compensatory role in JEHT.