Localization of thyroid peroxidase and the site of iodination in rat thyroid gland

The iodinated protein was localized in thyroid tissue slices by using radioautography. In unfixed tissue, the labelled protein was localized in the colloid, whereas, in tissue that was fixed before the 125I addition, the label was within the follicular cell. This localizes thyroid peroxidase largely...

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Bibliographic Details
Published inBiochemical journal Vol. 158; no. 2; pp. 477 - 479
Main Authors Edwards, H H, Morrison, M
Format Journal Article
LanguageEnglish
Published England 15.08.1976
Subjects
Animals
Autoradiography
Cyanides - pharmacology
Endoplasmic Reticulum - enzymology
In Vitro Techniques
Iodide Peroxidase - biosynthesis
Iodine Radioisotopes
Iodoproteins - biosynthesis
Peroxidases - biosynthesis
Rats
Thyroid Gland - metabolism
Thyroid Gland - ultrastructure
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Summary:The iodinated protein was localized in thyroid tissue slices by using radioautography. In unfixed tissue, the labelled protein was localized in the colloid, whereas, in tissue that was fixed before the 125I addition, the label was within the follicular cell. This localizes thyroid peroxidase largely on the endoplasmic reticulum of the cell.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0264-6021
0306-3283
1470-8728
DOI:10.1042/bj1580477