Screening of Elderly for Chronic Kidney Disease

• Published in: Kidney & blood pressure research Vol. 35; no. 6; pp. 497 - 503
• Main Authors: Ležaić, Višnja, Bajčetić, Sanja, Peruničić-Peković, Gordana, Bukvić, Danica, Dimković, Nada, Djukanović, Ljubica
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2012
• Subjects: Aged; Aged, 80 and over; Blood Pressure - physiology; Cross-Sectional Studies; Female; Glomerular Filtration Rate - physiology; Humans; Hypertension - diagnosis; Hypertension - epidemiology; Hypertension - physiopathology; Male; Mass Screening - methods; Middle Aged; Original Paper; Renal Insufficiency, Chronic - diagnosis; Renal Insufficiency, Chronic - epidemiology; Renal Insufficiency, Chronic - physiopathology; Kidney disease; Symptomless elderly; Microalbuminuria
• ISSN: 1420-4096; 1423-0143
• DOI: 10.1159/000332926

Background and Aims: The frequency of chronic kidney disease (CKD) markers was assessed in two groups of patients over 60 years – one without and the other with hypertension. Methods: The cross-sectional study involved 585 asymptomatic elderly patients (227 males), 93 without and 492 with hypertension. Data on patients were obtained by interview, analysis of medical records and physical examinations. Serum and urine creatinine, proteinuria, microalbuminuria (MAU, turbidimetry), and urinary sediment were analyzed. Results: Among the 585 patients, there were 54.5% with a positive family history for hypertension and 14% for kidney diseases. MAU was significantly more frequent (30 vs. 11%) and the mean estimated glomerular filtration rate (eGFR) higher (71 ± 14 vs. 64 ± 14 ml/min/1.73 m) in patients without hypertension than in those with hypertension. The majority of patients with stage 3 CKD had eGFR >45 ml/min/1.73 m 2 with normal urinary findings. Multivariate logistic regression analysis found age and treatment with angiotensin-converting enzyme inhibitors to be associated with reduced eGFR, MAU and proteinuria. In addition, smoking was associated with eGFR, but a family history for kidney disease and belonging to the group without hypertension were associated with MAU. Conclusion: The high prevalence of markers for CKD in symptomless elderly without hypertension confirmed that the elderly, as a high-risk population, should be screened based on increased age alone.