In-vitro evaluation of MPA-loaded electrospun coaxial fiber membranes for local treatment of glioblastoma tumor cells

• Published in: Journal of drug delivery science and technology Vol. 40; pp. 45 - 50
• Main Authors: Han, Daewoo, Sasaki, Mika, Yoshino, Hirofumi, Kofuji, Satoshi, Sasaki, Atsuo T., Steckl, Andrew J.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.08.2017
• Subjects: Brain cancer; Coaxial electrospinning; Drug delivery; Glioblastoma; Mycophenolic acid; Nanofiber; Nanofiber; Drug delivery; Mycophenolic acid; Coaxial electrospinning; Brain cancer; Glioblastoma

Core-sheath fibers containing a drug for brain tumor are reported. Mycophenolic acid (MPA), a FDA-approved immunosuppressant, has been demonstrated to inhibit several types of tumor cells growth. However, the effective serum MPA concentration for anti-tumor declines quickly in-vivo due to degradatio...