In-vitro evaluation of MPA-loaded electrospun coaxial fiber membranes for local treatment of glioblastoma tumor cells

Core-sheath fibers containing a drug for brain tumor are reported. Mycophenolic acid (MPA), a FDA-approved immunosuppressant, has been demonstrated to inhibit several types of tumor cells growth. However, the effective serum MPA concentration for anti-tumor declines quickly in-vivo due to degradatio...

Full description

Saved in:
Bibliographic Details
Published inJournal of drug delivery science and technology Vol. 40; pp. 45 - 50
Main Authors Han, Daewoo, Sasaki, Mika, Yoshino, Hirofumi, Kofuji, Satoshi, Sasaki, Atsuo T., Steckl, Andrew J.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.08.2017
Subjects
Brain cancer
Coaxial electrospinning
Drug delivery
Glioblastoma
Mycophenolic acid
Nanofiber
Nanofiber
Drug delivery
Mycophenolic acid
Coaxial electrospinning
Brain cancer
Glioblastoma
Online AccessGet full text

Cover

Abstract Core-sheath fibers containing a drug for brain tumor are reported. Mycophenolic acid (MPA), a FDA-approved immunosuppressant, has been demonstrated to inhibit several types of tumor cells growth. However, the effective serum MPA concentration for anti-tumor declines quickly in-vivo due to degradation in the liver, which hampers the development of MPA-based anti-tumor therapy. To overcome this issue, we have formed MPA-containing electrospun fiber membranes as local drug delivery vehicle and characterized MPA release profiles based on fiber composition and geometry. Coaxial fibers with poly(ε-caprolactone) (PCL)/MPA core and PCL sheath provided a more sustained release than homogenous fibers. In particular, thicker PCL sheath with 1:10 ratio of sheath thickness to fiber diameter provides gradual release in an initial period and higher MPA release after refreshing of media. The host polymer for MPA has a significant effect on the MPA release, with PCL/MPA single fiber providing more sustained release than coaxial fibers with polyvinylpyrrolidone (PVP)/MPA core and PCL sheath. In-vitro glioblastoma multiforme (GBM) tumor cell culture results show strong cell suppression effect by MPA-containing fiber membranes, with coaxial fiber membranes inhibiting GBM cell growth 3-5 × more than the single fiber membranes. This indicates that MPA-containing electrospun membranes have a promising potential for local treatment of GBM. [Display omitted]
AbstractList Core-sheath fibers containing a drug for brain tumor are reported. Mycophenolic acid (MPA), a FDA-approved immunosuppressant, has been demonstrated to inhibit several types of tumor cells growth. However, the effective serum MPA concentration for anti-tumor declines quickly in-vivo due to degradation in the liver, which hampers the development of MPA-based anti-tumor therapy. To overcome this issue, we have formed MPA-containing electrospun fiber membranes as local drug delivery vehicle and characterized MPA release profiles based on fiber composition and geometry. Coaxial fibers with poly(ε-caprolactone) (PCL)/MPA core and PCL sheath provided a more sustained release than homogenous fibers. In particular, thicker PCL sheath with 1:10 ratio of sheath thickness to fiber diameter provides gradual release in an initial period and higher MPA release after refreshing of media. The host polymer for MPA has a significant effect on the MPA release, with PCL/MPA single fiber providing more sustained release than coaxial fibers with polyvinylpyrrolidone (PVP)/MPA core and PCL sheath. In-vitro glioblastoma multiforme (GBM) tumor cell culture results show strong cell suppression effect by MPA-containing fiber membranes, with coaxial fiber membranes inhibiting GBM cell growth 3-5 × more than the single fiber membranes. This indicates that MPA-containing electrospun membranes have a promising potential for local treatment of GBM. [Display omitted]
Author Han, Daewoo
Steckl, Andrew J.
Sasaki, Mika
Yoshino, Hirofumi
Kofuji, Satoshi
Sasaki, Atsuo T.
Author_xml – sequence: 1
  givenname: Daewoo
  orcidid: 0000-0002-0689-555X
  surname: Han
  fullname: Han, Daewoo
  organization: Nanoelectronics Laboratory, Department of Electrical Engineering and Computing Systems, University of Cincinnati, Cincinnati, OH 45221, USA
– sequence: 2
  givenname: Mika
  surname: Sasaki
  fullname: Sasaki, Mika
  organization: Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
– sequence: 3
  givenname: Hirofumi
  surname: Yoshino
  fullname: Yoshino, Hirofumi
  organization: Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
– sequence: 4
  givenname: Satoshi
  surname: Kofuji
  fullname: Kofuji, Satoshi
  organization: Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
– sequence: 5
  givenname: Atsuo T.
  surname: Sasaki
  fullname: Sasaki, Atsuo T.
  organization: Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
– sequence: 6
  givenname: Andrew J.
  surname: Steckl
  fullname: Steckl, Andrew J.
  email: a.steckl@uc.edu
  organization: Nanoelectronics Laboratory, Department of Electrical Engineering and Computing Systems, University of Cincinnati, Cincinnati, OH 45221, USA
BookMark eNp9kM1OAyEUhVnUxFr7BG54gRlh_ugsXDSNf0mNLnRNGLgYJgw0wDT69lLr2tVJ7j3n5OS7QgvnHSB0Q0lJCe1ux3JUKqayIpSVpC2zLNCSMlYXVdWwS7SOcSQknwltqn6J5mdXHE0KHsNR2Fkk4x32Gr-8bQvrhQKFwYLMhniYHZZefBlhsTYDBDzBNAThIGLtA7Ze5k8KINIELp1aPq3xgxUx-UngNE_ZJcHaeI0utLAR1n-6Qh8P9--7p2L_-vi82-4LWXd9KgYl5SCprttqo0hLRcV0BwIqqjvd9MBo29REtZuGgpAdo4NoBWx0z9QgQXb1CtXnXpn3xwCaH4KZRPjmlPATMD7yX2D8BIyTlmfJqbtzCvK0o4HAozTgJCgTMgquvPk3_wOGSXyG
CitedBy_id crossref_primary_10_1016_j_drudis_2018_02_007
crossref_primary_10_3390_polym14235278
crossref_primary_10_1088_1748_605X_abbec8
crossref_primary_10_1088_2053_1591_ab5387
crossref_primary_10_29233_sdufeffd_589516
crossref_primary_10_3390_polym11122008
crossref_primary_10_1002_mabi_202100512
crossref_primary_10_1016_j_eng_2021_02_025
crossref_primary_10_1080_03639045_2022_2161559
crossref_primary_10_1016_j_msec_2019_01_130
crossref_primary_10_1021_acsbiomaterials_9b00853
crossref_primary_10_1515_ijmr_2023_0125
crossref_primary_10_3389_fbioe_2020_618516
crossref_primary_10_1002_smll_201801183
crossref_primary_10_1080_17425247_2020_1715938
crossref_primary_10_3390_cancers11091346
crossref_primary_10_1016_j_jddst_2023_104947
crossref_primary_10_1080_00405000_2018_1477237
crossref_primary_10_3390_ijms222313160
crossref_primary_10_1002_cplu_201900281
crossref_primary_10_3390_pharmaceutics15061649
crossref_primary_10_1016_j_ijpharm_2022_121584
crossref_primary_10_1016_j_colsurfb_2020_111110
crossref_primary_10_3390_biomedicines11010099
crossref_primary_10_3390_polym16081088
crossref_primary_10_1039_D2NH00328G
Cites_doi 10.1016/0304-3886(95)00041-8
10.2165/00003088-199834060-00002
10.1002/cncr.24398
10.1016/j.ejphar.2011.01.068
10.1021/nn504573u
10.1667/0033-7587(2007)168[183:HGUCTW]2.0.CO;2
10.1002/ijc.2910570421
10.1088/0957-4484/17/14/R01
10.1097/01.tp.0000253756.69243.65
10.1371/journal.pgen.1000832
10.1200/JCO.2003.05.063
10.1002/jbm.b.30510
10.1016/j.addr.2009.07.013
10.1016/j.msec.2014.04.053
10.1245/s10434-011-1588-4
10.1016/j.actbio.2017.02.029
10.1002/pc.10340
10.1111/php.12238
10.1097/FTD.0b013e318166eba0
10.1097/00007890-199508000-00003
10.1039/C6RA09558E
10.1016/j.biomaterials.2008.04.002
10.1016/j.canlet.2005.01.006
10.1002/adma.200400719
10.1002/wnan.1391
10.1038/nrd1414
10.1158/1078-0432.CCR-12-0720
10.1016/j.eurpolymj.2008.01.034
10.1155/2016/5385137
10.1021/am402376c
10.1021/la900660v
10.1016/S1470-2045(09)70025-7
10.1093/neuonc/nos273
10.1093/neuonc/noq052
10.1111/j.1525-1594.2006.00301.x
10.1021/am201064b
10.1039/c0jm03706k
10.1073/pnas.1211962109
10.1056/NEJMoa043330
10.1215/15228517-2008-078
10.1002/adma.200305136
10.1016/j.jconrel.2009.12.009
10.1159/000107356
ContentType Journal Article
Copyright 2017 Elsevier B.V.
Copyright_xml – notice: 2017 Elsevier B.V.
DBID AAYXX
CITATION
DOI 10.1016/j.jddst.2017.05.017
DatabaseName CrossRef
DatabaseTitle CrossRef
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
EndPage 50
ExternalDocumentID 10_1016_j_jddst_2017_05_017
S1773224717302071
GroupedDBID ---
--M
0R~
4.4
457
4G.
5GY
7-5
AACTN
AAEDT
AAEDW
AAIAV
AAKOC
AALRI
AAOAW
AATCM
AAXUO
ABMAC
ABYKQ
ACDAQ
ACGFS
ACRLP
ADBBV
ADEZE
AEBSH
AENEX
AFKWA
AFTJW
AFXIZ
AGHFR
AGUBO
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
AXJTR
BKOJK
BLXMC
EBS
EFJIC
EFLBG
EJD
F5P
FDB
FIRID
FYGXN
KOM
M41
O9-
OAUVE
ROL
SPCBC
SSP
SSZ
T5K
~G-
AAQFI
AAXKI
AAYXX
AFJKZ
AKRWK
CITATION
ID FETCH-LOGICAL-c369t-bdccbc1f3528d051a27f6eae21f6f49e715430d5841eac671ba5ae8f97dbcec63
IEDL.DBID AIKHN
ISSN 1773-2247
IngestDate Thu Sep 26 17:34:16 EDT 2024
Fri Feb 23 02:33:27 EST 2024
IsPeerReviewed true
IsScholarly true
Keywords Nanofiber
Drug delivery
Mycophenolic acid
Coaxial electrospinning
Brain cancer
Glioblastoma
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c369t-bdccbc1f3528d051a27f6eae21f6f49e715430d5841eac671ba5ae8f97dbcec63
ORCID 0000-0002-0689-555X
PageCount 6
ParticipantIDs crossref_primary_10_1016_j_jddst_2017_05_017
elsevier_sciencedirect_doi_10_1016_j_jddst_2017_05_017
PublicationCentury 2000
PublicationDate August 2017
2017-08-00
PublicationDateYYYYMMDD 2017-08-01
PublicationDate_xml – month: 08
  year: 2017
  text: August 2017
PublicationDecade 2010
PublicationTitle Journal of drug delivery science and technology
PublicationYear 2017
Publisher Elsevier B.V
Publisher_xml – name: Elsevier B.V
References Han, Steckl (bib11) 2013; 5
Bota, Desjardins, Quinn, Affronti, Friedman (bib43) 2007; 3
Ito, Camoriano, Seshadri, Evans, Kane, Skitzki (bib49) 2011; 18
Sollinger (bib24) 1995; 60
Feoktistova, Geserick, Leverkus (bib47) 2016; 4
Giese, Bjerkvig, Berens, Westphal (bib40) 2003; 21
Stupp, Mason, van den Bent, Weller, Fisher, Taphoorn, Belanger, Brandes, Marosi, Bogdahn, Curschmann, Janzer, Ludwin, Gorlia, Allgeier, Lacombe, Cairncross, Eisenhauer, Mirimanoff (bib35) 2005; 352
Chakraborty, Liao, Adler, Leong (bib3) 2009; 61
Lesniak, Brem (bib42) 2004; 3
Saraf, Baggett, Raphael, Kasper, Mikos (bib16) 2010; 143
Zheng, Yang, Lu, Zhang, Shui, Liu, He, Jiang, Zhao, Si (bib30) 2011; 658
Zhang, Duan, Yan, Yu, Ning, Zhao, Long (bib5) 2016; 6
Choi, Choi, Yoo (bib15) 2011; 21
Yang, Wang, Wang, Li, Guo, Zhou (bib21) 2015; 9
Wick, Platten, Weller (bib50) 2009; 11
Allison, Eugui (bib22) 1996; 10
Stupp, Hegi, Mason, van den Bent, Taphoorn, Janzer, Ludwin, Allgeier, Fisher, Belanger, Hau, Brandes, Gijtenbeek, Marosi, Vecht, Mokhtari, Wesseling, Villa, Eisenhauer, Gorlia, Weller, Lacombe, Cairncross, Mirimanoff (bib34) 2009; 10
Fenton, Nathanson, Ponte de Albuquerque, Kuga, Iwanami, Dang, Yang, Tanaka, Oba-Shinjo, Uno, del Mar Inda, Wykosky, Bachoo, James, DePinho, Vandenberg, Zhou, Marie, Mischel, Cavenee, Furnari (bib37) 2012; 109
Floryk, Huberman (bib27) 2006; 231
Li, Xia (bib4) 2004; 16
Drullion, Lagarde, Gioia, Legembre, Priault, Cardinaud, Lippert, Mahon, Pasquet (bib28) 2012; 2012
Doshi, Reneker (bib1) 1995; 35
Han, Sherman, Filocamo, Steckl (bib19) 2017; 53
Ting, Partovi, Levy, Riggs, Ensom (bib32) 2008; 30
Yan, Fan, Sun, Gao, Hao, Pei, Wang, Sun, Zhang (bib20) 2014; 41
Tressler, Garvin, Slate (bib26) 1994; 57
Sun, Zussman, Yarin, Wendorff, Greiner (bib9) 2003; 15
Harlow, Lane (bib48) 2006; 3
Jiang, Hu, Zhao, Li, Zhu (bib13) 2006; 79B
Bullingham, Nicholls, Kamm (bib31) 1998; 34
Han, Steckl (bib8) 2009; 25
Clark, Homer, O'Connor, Chen, Eskin, Lee, Merriman, Nelson (bib46) 2010; 6
Lu, Huang, Yu, Cardenas, Wei, Wujcik, Guo (bib14) 2016; 8
Jin, Prabhakaran, Ramakrishna (bib18) 2014; 90
Majd, Sumita, Yoshino, Chen, Terakawa, Daikoku, Kofuji, Curry, Wise-Draper, Warnick, Guarnaschelli, Sasaki (bib25) 2014; 2014
Xie, Jia, Xu, Hu, Wang, Jia (bib17) 2016; 2016
Fiorenza, Domann, Elizabeth, Stacia, Mackey (bib45) 2007; 168
Tuncyurek, Mayer, Klug, Dillmann, Henne-Bruns, Keller, Stracke (bib29) 2007; 39
Weller, Cloughesy, Perry, Wick (bib39) 2013; 15
Xin, Huang, Li, Jiang, Tong, Wang (bib10) 2008; 44
Teo, Ramakrishna (bib6) 2006; 17
Koehl, Wagner, Stoeltzing, Lang, Steinbauer, Schlitt, Geissler (bib33) 2007; 83
Salphati, Heffron, Alicke, Nishimura, Barck, Carano, Cheong, Edgar, Greve, Kharbanda, Koeppen, Lau, Lee, Pang, Plise, Pokorny, Reslan, Sarkaria, Wallin, Zhang, Gould, Olivero, Phillips (bib38) 2012; 18
Affronti, Heery, Herndon, Rich, Reardon, Desjardins, Vredenburgh, Friedman, Bigner, Friedman (bib41) 2009; 115
Akhavan, Cloughesy, Mischel (bib36) 2010; 12
Wiesel, Carl (bib23) 1998; 159
Ranganath, Wang (bib44) 2008; 29
Kim, Reneker (bib7) 1999; 20
Boudriot, Dersch, Greiner, Wendorff (bib2) 2006; 30
Han, Filocamo, Kirby, Steckl (bib12) 2011; 3
Bullingham (10.1016/j.jddst.2017.05.017_bib31) 1998; 34
Jin (10.1016/j.jddst.2017.05.017_bib18) 2014; 90
Giese (10.1016/j.jddst.2017.05.017_bib40) 2003; 21
Xin (10.1016/j.jddst.2017.05.017_bib10) 2008; 44
Clark (10.1016/j.jddst.2017.05.017_bib46) 2010; 6
Harlow (10.1016/j.jddst.2017.05.017_bib48) 2006; 3
Feoktistova (10.1016/j.jddst.2017.05.017_bib47) 2016; 4
Li (10.1016/j.jddst.2017.05.017_bib4) 2004; 16
Koehl (10.1016/j.jddst.2017.05.017_bib33) 2007; 83
Bota (10.1016/j.jddst.2017.05.017_bib43) 2007; 3
Yang (10.1016/j.jddst.2017.05.017_bib21) 2015; 9
Weller (10.1016/j.jddst.2017.05.017_bib39) 2013; 15
Affronti (10.1016/j.jddst.2017.05.017_bib41) 2009; 115
Wick (10.1016/j.jddst.2017.05.017_bib50) 2009; 11
Han (10.1016/j.jddst.2017.05.017_bib19) 2017; 53
Stupp (10.1016/j.jddst.2017.05.017_bib35) 2005; 352
Stupp (10.1016/j.jddst.2017.05.017_bib34) 2009; 10
Salphati (10.1016/j.jddst.2017.05.017_bib38) 2012; 18
Doshi (10.1016/j.jddst.2017.05.017_bib1) 1995; 35
Han (10.1016/j.jddst.2017.05.017_bib11) 2013; 5
Zheng (10.1016/j.jddst.2017.05.017_bib30) 2011; 658
Teo (10.1016/j.jddst.2017.05.017_bib6) 2006; 17
Kim (10.1016/j.jddst.2017.05.017_bib7) 1999; 20
Fenton (10.1016/j.jddst.2017.05.017_bib37) 2012; 109
Majd (10.1016/j.jddst.2017.05.017_bib25) 2014; 2014
Choi (10.1016/j.jddst.2017.05.017_bib15) 2011; 21
Ito (10.1016/j.jddst.2017.05.017_bib49) 2011; 18
Boudriot (10.1016/j.jddst.2017.05.017_bib2) 2006; 30
Floryk (10.1016/j.jddst.2017.05.017_bib27) 2006; 231
Akhavan (10.1016/j.jddst.2017.05.017_bib36) 2010; 12
Tressler (10.1016/j.jddst.2017.05.017_bib26) 1994; 57
Tuncyurek (10.1016/j.jddst.2017.05.017_bib29) 2007; 39
Ting (10.1016/j.jddst.2017.05.017_bib32) 2008; 30
Chakraborty (10.1016/j.jddst.2017.05.017_bib3) 2009; 61
Han (10.1016/j.jddst.2017.05.017_bib12) 2011; 3
Zhang (10.1016/j.jddst.2017.05.017_bib5) 2016; 6
Drullion (10.1016/j.jddst.2017.05.017_bib28) 2012; 2012
Jiang (10.1016/j.jddst.2017.05.017_bib13) 2006; 79B
Fiorenza (10.1016/j.jddst.2017.05.017_bib45) 2007; 168
Ranganath (10.1016/j.jddst.2017.05.017_bib44) 2008; 29
Han (10.1016/j.jddst.2017.05.017_bib8) 2009; 25
Wiesel (10.1016/j.jddst.2017.05.017_bib23) 1998; 159
Yan (10.1016/j.jddst.2017.05.017_bib20) 2014; 41
Lesniak (10.1016/j.jddst.2017.05.017_bib42) 2004; 3
Sun (10.1016/j.jddst.2017.05.017_bib9) 2003; 15
Lu (10.1016/j.jddst.2017.05.017_bib14) 2016; 8
Sollinger (10.1016/j.jddst.2017.05.017_bib24) 1995; 60
Saraf (10.1016/j.jddst.2017.05.017_bib16) 2010; 143
Xie (10.1016/j.jddst.2017.05.017_bib17) 2016; 2016
Allison (10.1016/j.jddst.2017.05.017_bib22) 1996; 10
References_xml – volume: 2012
  start-page: 9
  year: 2012
  ident: bib28
  article-title: Mycophenolic acid overcomes Imatinib and nilotinib resistance of chronic myeloid leukemia cells by apoptosis or a senescent-like cell cycle arrest
  publication-title: Leuk. Res. Treat.
  contributor:
    fullname: Pasquet
– volume: 57
  start-page: 568
  year: 1994
  end-page: 573
  ident: bib26
  article-title: Anti-tumor activity of mycophenolate mofetil against human and mouse tumors in vivo
  publication-title: Int. J. Cancer
  contributor:
    fullname: Slate
– volume: 6
  start-page: 53400
  year: 2016
  end-page: 53414
  ident: bib5
  article-title: Recent advances in melt electrospinning
  publication-title: RSC Adv.
  contributor:
    fullname: Long
– volume: 79B
  start-page: 50
  year: 2006
  end-page: 57
  ident: bib13
  article-title: Modulation of protein release from biodegradable core-shell structured fibers prepared by coaxial electrospinning
  publication-title: J. Biomed. Mater. Res. Part B Appl. Biomaterials
  contributor:
    fullname: Zhu
– volume: 60
  start-page: 225
  year: 1995
  end-page: 232
  ident: bib24
  article-title: Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients
  publication-title: Transplantation
  contributor:
    fullname: Sollinger
– volume: 34
  start-page: 429
  year: 1998
  end-page: 455
  ident: bib31
  article-title: Clinical pharmacokinetics of mycophenolate mofetil
  publication-title: Clin. Pharmacokinet.
  contributor:
    fullname: Kamm
– volume: 61
  start-page: 1043
  year: 2009
  end-page: 1054
  ident: bib3
  article-title: Electrohydrodynamics: a facile technique to fabricate drug delivery systems
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Leong
– volume: 17
  year: 2006
  ident: bib6
  article-title: A review on electrospinning design and nanofibre assemblies
  publication-title: Nanotechnology
  contributor:
    fullname: Ramakrishna
– volume: 15
  start-page: 1929
  year: 2003
  end-page: 1932
  ident: bib9
  article-title: Compound core-shell polymer nanofibers by co-electrospinning
  publication-title: Adv. Mater
  contributor:
    fullname: Greiner
– volume: 12
  start-page: 882
  year: 2010
  end-page: 889
  ident: bib36
  article-title: mTOR signaling in glioblastoma: lessons learned from bench to bedside
  publication-title: Neuro. Oncol.
  contributor:
    fullname: Mischel
– volume: 20
  start-page: 124
  year: 1999
  end-page: 131
  ident: bib7
  article-title: Mechanical properties of composites using ultrafine electrospun fibers
  publication-title: Polym. Compos.
  contributor:
    fullname: Reneker
– volume: 41
  start-page: 217
  year: 2014
  end-page: 223
  ident: bib20
  article-title: Biocompatible core-shell electrospun nanofibers as potential application for chemotherapy against ovary cancer
  publication-title: Mater. Sci. Eng. C
  contributor:
    fullname: Zhang
– volume: 3
  year: 2006
  ident: bib48
  article-title: Fixing attached cells in paraformaldehyde
  publication-title: Cold Spring Harb. Protoc. 2006
  contributor:
    fullname: Lane
– volume: 30
  start-page: 785
  year: 2006
  end-page: 792
  ident: bib2
  article-title: Electrospinning approaches toward Scaffold engineering-a brief overview
  publication-title: Artif. Organs
  contributor:
    fullname: Wendorff
– volume: 143
  start-page: 95
  year: 2010
  end-page: 103
  ident: bib16
  article-title: Regulated non-viral gene delivery from coaxial electrospun fiber mesh scaffolds
  publication-title: J. Control. release Official J. Control. Release Soc.
  contributor:
    fullname: Mikos
– volume: 16
  start-page: 1151
  year: 2004
  end-page: 1170
  ident: bib4
  article-title: Electrospinning of nanofibers: reinventing the wheel?
  publication-title: Adv. Mater
  contributor:
    fullname: Xia
– volume: 109
  start-page: 14164
  year: 2012
  end-page: 14169
  ident: bib37
  article-title: Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Furnari
– volume: 39
  start-page: 380
  year: 2007
  end-page: 387
  ident: bib29
  article-title: Everolimus and mycophenolate mofetil sensitize human pancreatic cancer cells to Gemcitabine in vitro: a novel adjunct to standard chemotherapy?
  publication-title: Eur. Surg. Res.
  contributor:
    fullname: Stracke
– volume: 11
  start-page: 69
  year: 2009
  end-page: 79
  ident: bib50
  article-title: New (alternative) temozolomide regimens for the treatment of glioma
  publication-title: Neuro-Oncology
  contributor:
    fullname: Weller
– volume: 115
  start-page: 3501
  year: 2009
  end-page: 3511
  ident: bib41
  article-title: Overall survival of newly diagnosed glioblastoma patients receiving carmustine wafers followed by radiation and concurrent temozolomide plus rotational multiagent chemotherapy
  publication-title: Cancer
  contributor:
    fullname: Friedman
– volume: 3
  start-page: 499
  year: 2004
  end-page: 508
  ident: bib42
  article-title: Targeted therapy for brain tumours
  publication-title: Nat. Rev. Drug Discov.
  contributor:
    fullname: Brem
– volume: 3
  start-page: 707
  year: 2007
  end-page: 715
  ident: bib43
  article-title: Interstitial chemotherapy with biodegradable BCNU (Gliadel(
  publication-title: Ther. Clin. Risk Manag.
  contributor:
    fullname: Friedman
– volume: 2016
  start-page: 5385137
  year: 2016
  ident: bib17
  article-title: Fabrication of core-shell PEI/pBMP2-PLGA electrospun scaffold for gene delivery to periodontal ligament stem cells
  publication-title: Stem Cells Int.
  contributor:
    fullname: Jia
– volume: 168
  start-page: 183
  year: 2007
  end-page: 192
  ident: bib45
  article-title: Human glioblastoma U87MG cells transduced with a dominant negative p53 (TP53) adenovirus construct undergo radiation-induced mitotic catastrophe
  publication-title: Radiat. Res.
  contributor:
    fullname: Mackey
– volume: 18
  start-page: 6239
  year: 2012
  end-page: 6248
  ident: bib38
  article-title: Targeting the PI3K pathway in the brain—efficacy of a PI3K inhibitor optimized to cross the blood–brain barrier
  publication-title: Clin. Cancer Res.
  contributor:
    fullname: Phillips
– volume: 658
  start-page: 1
  year: 2011
  end-page: 8
  ident: bib30
  article-title: Mycophenolic acid induces adipocyte-like differentiation and reversal of malignancy of breast cancer cells partly through PPARγ
  publication-title: Eur. J. Pharmacol.
  contributor:
    fullname: Si
– volume: 90
  start-page: 673
  year: 2014
  end-page: 681
  ident: bib18
  article-title: Photosensitive and biomimetic core-shell nanofibrous scaffolds as wound dressing
  publication-title: Photochem. Photobiol.
  contributor:
    fullname: Ramakrishna
– volume: 5
  start-page: 8241
  year: 2013
  end-page: 8245
  ident: bib11
  article-title: Triaxial electrospun nanofiber membranes for controlled dual release of functional molecules
  publication-title: ACS Appl. Mater. Interfaces
  contributor:
    fullname: Steckl
– volume: 30
  start-page: 282
  year: 2008
  end-page: 291
  ident: bib32
  article-title: Pharmacokinetics of mycophenolic acid and its phenolic-glucuronide and acyl Glucuronide metabolites in stable thoracic transplant recipients
  publication-title: Ther. Drug Monit.
  contributor:
    fullname: Ensom
– volume: 8
  start-page: 654
  year: 2016
  end-page: 677
  ident: bib14
  article-title: Coaxial electrospun fibers: applications in drug delivery and tissue engineering
  publication-title: Wiley Interdiscip. Rev. Nanomedicine Nanobiotechnology
  contributor:
    fullname: Guo
– volume: 15
  start-page: 4
  year: 2013
  end-page: 27
  ident: bib39
  article-title: Standards of care for treatment of recurrent glioblastoma—are we there yet?
  publication-title: Neuro. Oncol.
  contributor:
    fullname: Wick
– volume: 9
  start-page: 1161
  year: 2015
  end-page: 1174
  ident: bib21
  article-title: An implantable active-targeting micelle-in-nanofiber device for efficient and safe cancer therapy
  publication-title: ACS Nano
  contributor:
    fullname: Zhou
– volume: 10
  start-page: 77
  year: 1996
  end-page: 84
  ident: bib22
  article-title: Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF)
  publication-title: Clin. Transpl.
  contributor:
    fullname: Eugui
– volume: 3
  start-page: 4633
  year: 2011
  end-page: 4639
  ident: bib12
  article-title: Deactivating chemical agents using enzyme-coated nanofibers formed by electrospinning
  publication-title: ACS Appl. Mater. Interfaces
  contributor:
    fullname: Steckl
– volume: 83
  start-page: 607
  year: 2007
  end-page: 614
  ident: bib33
  article-title: Mycophenolate mofetil inhibits tumor growth and angiogenesis in vitro but has variable antitumor effects in vivo, possibly related to bioavailability
  publication-title: Transplantation
  contributor:
    fullname: Geissler
– volume: 18
  start-page: 2357
  year: 2011
  end-page: 2363
  ident: bib49
  article-title: Water: a simple solution for tumor spillage
  publication-title: Ann. Surg. Oncol.
  contributor:
    fullname: Skitzki
– volume: 4
  year: 2016
  ident: bib47
  article-title: Crystal violet assay for determining viability of cultured cells
  publication-title: Cold Spring Harb. Protoc. 2016
  contributor:
    fullname: Leverkus
– volume: 2014
  start-page: 12
  year: 2014
  ident: bib25
  article-title: A review of the potential utility of mycophenolate mofetil as a cancer therapeutic
  publication-title: J. Cancer Res.
  contributor:
    fullname: Sasaki
– volume: 6
  start-page: e1000832
  year: 2010
  ident: bib46
  article-title: U87MG decoded: the genomic sequence of a cytogenetically aberrant human cancer cell line
  publication-title: PLoS Genet.
  contributor:
    fullname: Nelson
– volume: 35
  start-page: 151
  year: 1995
  end-page: 160
  ident: bib1
  article-title: Electrospinning process and applications of electrospun fibers
  publication-title: J. Electrostat
  contributor:
    fullname: Reneker
– volume: 53
  start-page: 242
  year: 2017
  end-page: 249
  ident: bib19
  article-title: Long-term antimicrobial effect of nisin released from electrospun triaxial fiber membranes
  publication-title: Acta Biomater.
  contributor:
    fullname: Steckl
– volume: 29
  start-page: 2996
  year: 2008
  end-page: 3003
  ident: bib44
  article-title: Biodegradable microfiber implants delivering paclitaxel for post-surgical chemotherapy against malignant glioma
  publication-title: Biomaterials
  contributor:
    fullname: Wang
– volume: 25
  start-page: 9454
  year: 2009
  end-page: 9462
  ident: bib8
  article-title: Superhydrophobic and oleophobic fibers by coaxial electrospinning
  publication-title: Langmuir
  contributor:
    fullname: Steckl
– volume: 352
  start-page: 987
  year: 2005
  end-page: 996
  ident: bib35
  article-title: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
  publication-title: N. Engl. J. Med.
  contributor:
    fullname: Mirimanoff
– volume: 10
  start-page: 459
  year: 2009
  end-page: 466
  ident: bib34
  article-title: Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
  publication-title: Lancet Oncol.
  contributor:
    fullname: Mirimanoff
– volume: 21
  start-page: 5258
  year: 2011
  end-page: 5267
  ident: bib15
  article-title: Coaxial electrospun nanofibers for treatment of diabetic ulcers with binary release of multiple growth factors
  publication-title: J. Mater. Chem.
  contributor:
    fullname: Yoo
– volume: 159
  start-page: 28
  year: 1998
  end-page: 33
  ident: bib23
  article-title: A placeco controlled study of mycophenolate mofetil used in combination with cyclosporine and corticosteroids for the prevention of acute rejection in renal allograft recipents: 1-year results
  publication-title: J. Urol.
  contributor:
    fullname: Carl
– volume: 21
  start-page: 1624
  year: 2003
  end-page: 1636
  ident: bib40
  article-title: Cost of migration: invasion of malignant gliomas and implications for treatment
  publication-title: J. Clin. Oncol.
  contributor:
    fullname: Westphal
– volume: 231
  start-page: 20
  year: 2006
  end-page: 29
  ident: bib27
  article-title: Mycophenolic acid-induced replication arrest, differentiation markers and cell death of androgen-independent prostate cancer cells DU145
  publication-title: Cancer Lett.
  contributor:
    fullname: Huberman
– volume: 44
  start-page: 1040
  year: 2008
  end-page: 1045
  ident: bib10
  article-title: Core-sheath functional polymer nanofibers prepared by co-electrospinning
  publication-title: Eur. Polym. J.
  contributor:
    fullname: Wang
– volume: 35
  start-page: 151
  year: 1995
  ident: 10.1016/j.jddst.2017.05.017_bib1
  article-title: Electrospinning process and applications of electrospun fibers
  publication-title: J. Electrostat
  doi: 10.1016/0304-3886(95)00041-8
  contributor:
    fullname: Doshi
– volume: 34
  start-page: 429
  issue: 6
  year: 1998
  ident: 10.1016/j.jddst.2017.05.017_bib31
  article-title: Clinical pharmacokinetics of mycophenolate mofetil
  publication-title: Clin. Pharmacokinet.
  doi: 10.2165/00003088-199834060-00002
  contributor:
    fullname: Bullingham
– volume: 115
  start-page: 3501
  issue: 15
  year: 2009
  ident: 10.1016/j.jddst.2017.05.017_bib41
  article-title: Overall survival of newly diagnosed glioblastoma patients receiving carmustine wafers followed by radiation and concurrent temozolomide plus rotational multiagent chemotherapy
  publication-title: Cancer
  doi: 10.1002/cncr.24398
  contributor:
    fullname: Affronti
– volume: 658
  start-page: 1
  issue: 1
  year: 2011
  ident: 10.1016/j.jddst.2017.05.017_bib30
  article-title: Mycophenolic acid induces adipocyte-like differentiation and reversal of malignancy of breast cancer cells partly through PPARγ
  publication-title: Eur. J. Pharmacol.
  doi: 10.1016/j.ejphar.2011.01.068
  contributor:
    fullname: Zheng
– volume: 9
  start-page: 1161
  issue: 2
  year: 2015
  ident: 10.1016/j.jddst.2017.05.017_bib21
  article-title: An implantable active-targeting micelle-in-nanofiber device for efficient and safe cancer therapy
  publication-title: ACS Nano
  doi: 10.1021/nn504573u
  contributor:
    fullname: Yang
– volume: 168
  start-page: 183
  issue: 2
  year: 2007
  ident: 10.1016/j.jddst.2017.05.017_bib45
  article-title: Human glioblastoma U87MG cells transduced with a dominant negative p53 (TP53) adenovirus construct undergo radiation-induced mitotic catastrophe
  publication-title: Radiat. Res.
  doi: 10.1667/0033-7587(2007)168[183:HGUCTW]2.0.CO;2
  contributor:
    fullname: Fiorenza
– volume: 57
  start-page: 568
  issue: 4
  year: 1994
  ident: 10.1016/j.jddst.2017.05.017_bib26
  article-title: Anti-tumor activity of mycophenolate mofetil against human and mouse tumors in vivo
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.2910570421
  contributor:
    fullname: Tressler
– volume: 17
  issue: 14
  year: 2006
  ident: 10.1016/j.jddst.2017.05.017_bib6
  article-title: A review on electrospinning design and nanofibre assemblies
  publication-title: Nanotechnology
  doi: 10.1088/0957-4484/17/14/R01
  contributor:
    fullname: Teo
– volume: 83
  start-page: 607
  issue: 5
  year: 2007
  ident: 10.1016/j.jddst.2017.05.017_bib33
  article-title: Mycophenolate mofetil inhibits tumor growth and angiogenesis in vitro but has variable antitumor effects in vivo, possibly related to bioavailability
  publication-title: Transplantation
  doi: 10.1097/01.tp.0000253756.69243.65
  contributor:
    fullname: Koehl
– volume: 6
  start-page: e1000832
  issue: 1
  year: 2010
  ident: 10.1016/j.jddst.2017.05.017_bib46
  article-title: U87MG decoded: the genomic sequence of a cytogenetically aberrant human cancer cell line
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1000832
  contributor:
    fullname: Clark
– volume: 21
  start-page: 1624
  issue: 8
  year: 2003
  ident: 10.1016/j.jddst.2017.05.017_bib40
  article-title: Cost of migration: invasion of malignant gliomas and implications for treatment
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2003.05.063
  contributor:
    fullname: Giese
– volume: 79B
  start-page: 50
  issue: 1
  year: 2006
  ident: 10.1016/j.jddst.2017.05.017_bib13
  article-title: Modulation of protein release from biodegradable core-shell structured fibers prepared by coaxial electrospinning
  publication-title: J. Biomed. Mater. Res. Part B Appl. Biomaterials
  doi: 10.1002/jbm.b.30510
  contributor:
    fullname: Jiang
– volume: 61
  start-page: 1043
  year: 2009
  ident: 10.1016/j.jddst.2017.05.017_bib3
  article-title: Electrohydrodynamics: a facile technique to fabricate drug delivery systems
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2009.07.013
  contributor:
    fullname: Chakraborty
– volume: 4
  year: 2016
  ident: 10.1016/j.jddst.2017.05.017_bib47
  article-title: Crystal violet assay for determining viability of cultured cells
  publication-title: Cold Spring Harb. Protoc. 2016
  contributor:
    fullname: Feoktistova
– volume: 41
  start-page: 217
  year: 2014
  ident: 10.1016/j.jddst.2017.05.017_bib20
  article-title: Biocompatible core-shell electrospun nanofibers as potential application for chemotherapy against ovary cancer
  publication-title: Mater. Sci. Eng. C
  doi: 10.1016/j.msec.2014.04.053
  contributor:
    fullname: Yan
– volume: 18
  start-page: 2357
  issue: 8
  year: 2011
  ident: 10.1016/j.jddst.2017.05.017_bib49
  article-title: Water: a simple solution for tumor spillage
  publication-title: Ann. Surg. Oncol.
  doi: 10.1245/s10434-011-1588-4
  contributor:
    fullname: Ito
– volume: 53
  start-page: 242
  year: 2017
  ident: 10.1016/j.jddst.2017.05.017_bib19
  article-title: Long-term antimicrobial effect of nisin released from electrospun triaxial fiber membranes
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2017.02.029
  contributor:
    fullname: Han
– volume: 20
  start-page: 124
  issue: 1
  year: 1999
  ident: 10.1016/j.jddst.2017.05.017_bib7
  article-title: Mechanical properties of composites using ultrafine electrospun fibers
  publication-title: Polym. Compos.
  doi: 10.1002/pc.10340
  contributor:
    fullname: Kim
– volume: 2014
  start-page: 12
  year: 2014
  ident: 10.1016/j.jddst.2017.05.017_bib25
  article-title: A review of the potential utility of mycophenolate mofetil as a cancer therapeutic
  publication-title: J. Cancer Res.
  contributor:
    fullname: Majd
– volume: 90
  start-page: 673
  issue: 3
  year: 2014
  ident: 10.1016/j.jddst.2017.05.017_bib18
  article-title: Photosensitive and biomimetic core-shell nanofibrous scaffolds as wound dressing
  publication-title: Photochem. Photobiol.
  doi: 10.1111/php.12238
  contributor:
    fullname: Jin
– volume: 30
  start-page: 282
  issue: 3
  year: 2008
  ident: 10.1016/j.jddst.2017.05.017_bib32
  article-title: Pharmacokinetics of mycophenolic acid and its phenolic-glucuronide and acyl Glucuronide metabolites in stable thoracic transplant recipients
  publication-title: Ther. Drug Monit.
  doi: 10.1097/FTD.0b013e318166eba0
  contributor:
    fullname: Ting
– volume: 3
  year: 2006
  ident: 10.1016/j.jddst.2017.05.017_bib48
  article-title: Fixing attached cells in paraformaldehyde
  publication-title: Cold Spring Harb. Protoc. 2006
  contributor:
    fullname: Harlow
– volume: 60
  start-page: 225
  issue: 3
  year: 1995
  ident: 10.1016/j.jddst.2017.05.017_bib24
  article-title: Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients
  publication-title: Transplantation
  doi: 10.1097/00007890-199508000-00003
  contributor:
    fullname: Sollinger
– volume: 6
  start-page: 53400
  issue: 58
  year: 2016
  ident: 10.1016/j.jddst.2017.05.017_bib5
  article-title: Recent advances in melt electrospinning
  publication-title: RSC Adv.
  doi: 10.1039/C6RA09558E
  contributor:
    fullname: Zhang
– volume: 29
  start-page: 2996
  issue: 20
  year: 2008
  ident: 10.1016/j.jddst.2017.05.017_bib44
  article-title: Biodegradable microfiber implants delivering paclitaxel for post-surgical chemotherapy against malignant glioma
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2008.04.002
  contributor:
    fullname: Ranganath
– volume: 159
  start-page: 28
  issue: 1
  year: 1998
  ident: 10.1016/j.jddst.2017.05.017_bib23
  article-title: A placeco controlled study of mycophenolate mofetil used in combination with cyclosporine and corticosteroids for the prevention of acute rejection in renal allograft recipents: 1-year results
  publication-title: J. Urol.
  contributor:
    fullname: Wiesel
– volume: 231
  start-page: 20
  issue: 1
  year: 2006
  ident: 10.1016/j.jddst.2017.05.017_bib27
  article-title: Mycophenolic acid-induced replication arrest, differentiation markers and cell death of androgen-independent prostate cancer cells DU145
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2005.01.006
  contributor:
    fullname: Floryk
– volume: 16
  start-page: 1151
  issue: 14
  year: 2004
  ident: 10.1016/j.jddst.2017.05.017_bib4
  article-title: Electrospinning of nanofibers: reinventing the wheel?
  publication-title: Adv. Mater
  doi: 10.1002/adma.200400719
  contributor:
    fullname: Li
– volume: 8
  start-page: 654
  issue: 5
  year: 2016
  ident: 10.1016/j.jddst.2017.05.017_bib14
  article-title: Coaxial electrospun fibers: applications in drug delivery and tissue engineering
  publication-title: Wiley Interdiscip. Rev. Nanomedicine Nanobiotechnology
  doi: 10.1002/wnan.1391
  contributor:
    fullname: Lu
– volume: 3
  start-page: 499
  issue: 6
  year: 2004
  ident: 10.1016/j.jddst.2017.05.017_bib42
  article-title: Targeted therapy for brain tumours
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd1414
  contributor:
    fullname: Lesniak
– volume: 18
  start-page: 6239
  issue: 22
  year: 2012
  ident: 10.1016/j.jddst.2017.05.017_bib38
  article-title: Targeting the PI3K pathway in the brain—efficacy of a PI3K inhibitor optimized to cross the blood–brain barrier
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-12-0720
  contributor:
    fullname: Salphati
– volume: 3
  start-page: 707
  issue: 5
  year: 2007
  ident: 10.1016/j.jddst.2017.05.017_bib43
  article-title: Interstitial chemotherapy with biodegradable BCNU (Gliadel(®)) wafers in the treatment of malignant gliomas
  publication-title: Ther. Clin. Risk Manag.
  contributor:
    fullname: Bota
– volume: 44
  start-page: 1040
  issue: 4
  year: 2008
  ident: 10.1016/j.jddst.2017.05.017_bib10
  article-title: Core-sheath functional polymer nanofibers prepared by co-electrospinning
  publication-title: Eur. Polym. J.
  doi: 10.1016/j.eurpolymj.2008.01.034
  contributor:
    fullname: Xin
– volume: 2016
  start-page: 5385137
  year: 2016
  ident: 10.1016/j.jddst.2017.05.017_bib17
  article-title: Fabrication of core-shell PEI/pBMP2-PLGA electrospun scaffold for gene delivery to periodontal ligament stem cells
  publication-title: Stem Cells Int.
  doi: 10.1155/2016/5385137
  contributor:
    fullname: Xie
– volume: 5
  start-page: 8241
  issue: 16
  year: 2013
  ident: 10.1016/j.jddst.2017.05.017_bib11
  article-title: Triaxial electrospun nanofiber membranes for controlled dual release of functional molecules
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/am402376c
  contributor:
    fullname: Han
– volume: 10
  start-page: 77
  year: 1996
  ident: 10.1016/j.jddst.2017.05.017_bib22
  article-title: Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF)
  publication-title: Clin. Transpl.
  contributor:
    fullname: Allison
– volume: 25
  start-page: 9454
  year: 2009
  ident: 10.1016/j.jddst.2017.05.017_bib8
  article-title: Superhydrophobic and oleophobic fibers by coaxial electrospinning
  publication-title: Langmuir
  doi: 10.1021/la900660v
  contributor:
    fullname: Han
– volume: 10
  start-page: 459
  issue: 5
  year: 2009
  ident: 10.1016/j.jddst.2017.05.017_bib34
  article-title: Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
  publication-title: Lancet Oncol.
  doi: 10.1016/S1470-2045(09)70025-7
  contributor:
    fullname: Stupp
– volume: 15
  start-page: 4
  issue: 1
  year: 2013
  ident: 10.1016/j.jddst.2017.05.017_bib39
  article-title: Standards of care for treatment of recurrent glioblastoma—are we there yet?
  publication-title: Neuro. Oncol.
  doi: 10.1093/neuonc/nos273
  contributor:
    fullname: Weller
– volume: 12
  start-page: 882
  issue: 8
  year: 2010
  ident: 10.1016/j.jddst.2017.05.017_bib36
  article-title: mTOR signaling in glioblastoma: lessons learned from bench to bedside
  publication-title: Neuro. Oncol.
  doi: 10.1093/neuonc/noq052
  contributor:
    fullname: Akhavan
– volume: 30
  start-page: 785
  issue: 10
  year: 2006
  ident: 10.1016/j.jddst.2017.05.017_bib2
  article-title: Electrospinning approaches toward Scaffold engineering-a brief overview
  publication-title: Artif. Organs
  doi: 10.1111/j.1525-1594.2006.00301.x
  contributor:
    fullname: Boudriot
– volume: 3
  start-page: 4633
  issue: 12
  year: 2011
  ident: 10.1016/j.jddst.2017.05.017_bib12
  article-title: Deactivating chemical agents using enzyme-coated nanofibers formed by electrospinning
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/am201064b
  contributor:
    fullname: Han
– volume: 21
  start-page: 5258
  issue: 14
  year: 2011
  ident: 10.1016/j.jddst.2017.05.017_bib15
  article-title: Coaxial electrospun nanofibers for treatment of diabetic ulcers with binary release of multiple growth factors
  publication-title: J. Mater. Chem.
  doi: 10.1039/c0jm03706k
  contributor:
    fullname: Choi
– volume: 109
  start-page: 14164
  issue: 35
  year: 2012
  ident: 10.1016/j.jddst.2017.05.017_bib37
  article-title: Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1211962109
  contributor:
    fullname: Fenton
– volume: 352
  start-page: 987
  issue: 10
  year: 2005
  ident: 10.1016/j.jddst.2017.05.017_bib35
  article-title: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa043330
  contributor:
    fullname: Stupp
– volume: 2012
  start-page: 9
  year: 2012
  ident: 10.1016/j.jddst.2017.05.017_bib28
  article-title: Mycophenolic acid overcomes Imatinib and nilotinib resistance of chronic myeloid leukemia cells by apoptosis or a senescent-like cell cycle arrest
  publication-title: Leuk. Res. Treat.
  contributor:
    fullname: Drullion
– volume: 11
  start-page: 69
  issue: 1
  year: 2009
  ident: 10.1016/j.jddst.2017.05.017_bib50
  article-title: New (alternative) temozolomide regimens for the treatment of glioma
  publication-title: Neuro-Oncology
  doi: 10.1215/15228517-2008-078
  contributor:
    fullname: Wick
– volume: 15
  start-page: 1929
  issue: 22
  year: 2003
  ident: 10.1016/j.jddst.2017.05.017_bib9
  article-title: Compound core-shell polymer nanofibers by co-electrospinning
  publication-title: Adv. Mater
  doi: 10.1002/adma.200305136
  contributor:
    fullname: Sun
– volume: 143
  start-page: 95
  issue: 1
  year: 2010
  ident: 10.1016/j.jddst.2017.05.017_bib16
  article-title: Regulated non-viral gene delivery from coaxial electrospun fiber mesh scaffolds
  publication-title: J. Control. release Official J. Control. Release Soc.
  doi: 10.1016/j.jconrel.2009.12.009
  contributor:
    fullname: Saraf
– volume: 39
  start-page: 380
  issue: 6
  year: 2007
  ident: 10.1016/j.jddst.2017.05.017_bib29
  article-title: Everolimus and mycophenolate mofetil sensitize human pancreatic cancer cells to Gemcitabine in vitro: a novel adjunct to standard chemotherapy?
  publication-title: Eur. Surg. Res.
  doi: 10.1159/000107356
  contributor:
    fullname: Tuncyurek
SSID ssj0001701429
Score 2.2954698
Snippet Core-sheath fibers containing a drug for brain tumor are reported. Mycophenolic acid (MPA), a FDA-approved immunosuppressant, has been demonstrated to inhibit...
SourceID crossref
elsevier
SourceType Aggregation Database
Publisher
StartPage 45
SubjectTerms Brain cancer
Coaxial electrospinning
Drug delivery
Glioblastoma
Mycophenolic acid
Nanofiber
Title In-vitro evaluation of MPA-loaded electrospun coaxial fiber membranes for local treatment of glioblastoma tumor cells
URI https://dx.doi.org/10.1016/j.jddst.2017.05.017
Volume 40
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba8IwFA6iL3sZuzJ3Iw_DJ4O9xMY-ikx0osimzLeSNMlQtBWtY_77nfQyNxh72FNo6SklOf3Ol-ScLwg9mMoP6WhKFAAwoaFrEeEIQcCZeMsXLrBgUzs8HHm9KX2aNWcl1ClqYUxaZY79GaanaJ3faeS92VjP540XmzHwRmq2kYHzmDryCoQjp1VGlXZ_0BsdlloYzAPS88qMCTE2hf5Qmum1kHJr0irtXMST_R6jvsWd7gk6zgkjbmffdIpKKjpDtXGmOL2v48mhgGpbxzU8PmhR78_Rrh-R93myifFB1hvHGg_HbbKMuVQS5wfhbNe7CIcx_wCHxNrkkeCVWsFcGrAQA7PFadTDX4np5i1vy3ksgH4n8YrjZLeCp8xGwPYCTbuPk06P5CctkND1_IQIGYYitLWRepHwm3KHaU9x5dja09RXDIiWa0kgKzYAtcdswZtctbTPpAhV6LmXqBzFkbpC2HfBJyzma8kptYTt8xZMeoDYcKO0TmkV1Yu-DdaZoEZQZJotgnQoAjMUgdUMoKkir-j_4IdfBAD5fxle_9fwBh2ZqyzJ7xaVk81O3QHxSMR97limHTy_Dj4B5EDbRg
link.rule.ids 315,783,787,24128,27936,27937,45691
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1dS8MwFA2yPeiL-InzMw_i08LaNWvWxzGUTt0YOGFvIWkS2dja4TrRf-9NP6yC-OBToe0tJbk9OWnOPUHo2lZ-qLahRAMAExp5DpFtKQkkk-gG0gMWbGuHhyM_fKb30850C_XLWhgrqyywP8f0DK2LM62iNVur2az15DIG2UjtMjJwHltHXgc2EMDXWe8NHsJR9auFwTwg26_MhhAbU_oPZUqvuVJrK6t0CxNP9vsY9W3cudtDuwVhxL38nfbRlo4P0M04d5z-aOJJVUC1buIbPK68qD8O0WYQk7dZ-prgytYbJwYPxz2ySITSChcb4axXmxhHiXiHhMTG6kjwUi9hLg1YiIHZ4mzUw1_CdPuUl8UskUC_02QpcLpZwl12IWB9hJ7vbif9kBQ7LZDI84OUSBVFMnKNtXpR8JmKNjO-FrrtGt_QQDMgWp6jgKy4ANQ-c6XoCN01AVMy0pHvHaNanMT6BOHAg5xwWGCUoNSRbiC6MOkBYiOs0zqlDdQs25avckMNXirN5jzrCm67gjsdDocG8sv25z_yggPk_xV4-t_AK7QdToaP_HEwejhDO_ZKLvg7R7X0daMvgISk8rJIsk943NyV
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=In-vitro+evaluation+of+MPA-loaded+electrospun+coaxial+fiber+membranes+for+local+treatment+of+glioblastoma+tumor+cells&rft.jtitle=Journal+of+drug+delivery+science+and+technology&rft.au=Han%2C+Daewoo&rft.au=Sasaki%2C+Mika&rft.au=Yoshino%2C+Hirofumi&rft.au=Kofuji%2C+Satoshi&rft.date=2017-08-01&rft.pub=Elsevier+B.V&rft.issn=1773-2247&rft.volume=40&rft.spage=45&rft.epage=50&rft_id=info:doi/10.1016%2Fj.jddst.2017.05.017&rft.externalDocID=S1773224717302071
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1773-2247&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1773-2247&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1773-2247&client=summon