Significance of lymphatic invasion and proliferation on regional lymph node metastasis in renal cell carcinoma

• Published in: American journal of clinical pathology Vol. 128; no. 2; pp. 198 - 207
• Main Authors: ISHIKAWA, Yukio, AIDA, Shinsuke, ISHIGURO, Shigeki, NISHIMURA, Chiaki, KAMATA, Itaru, SHIMOKAWA, Reiko, ISHII, Toshiharu, TAMAI, Seiichi, AKASAKA, Yoshikiyo, KIGUCHI, Hideko, AKISHIMA-FUKASAWA, Yuri, HAYAKAWA, Masamichi, SOH, Shigehiro, ITO, Kinji, KIMURA-MATSUMOTO, Masayo
• Format: Journal Article
• Language: English
• Published: Chicago, IL American Society of Clinical Pathologists 01.08.2007
• Subjects: Adult; Aged; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal, Murine-Derived; Biological and medical sciences; Carcinoma, Renal Cell - pathology; Cell Proliferation; Female; Hematologic and hematopoietic diseases; Humans; Immunohistochemistry; Investigative techniques, diagnostic techniques (general aspects); Kidney Neoplasms - pathology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphatic Metastasis; Male; Medical sciences; Middle Aged; Multivariate Analysis; Neoplasm Invasiveness; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Vascular Endothelial Growth Factor C - analysis; Cell proliferation; Carcinoma; Lymphatic invasion; Malignant lymphadenopathy; Tumorous infiltration; Regional; Density; Renal cell carcinoma; Grawitz tumor; Vascular endothelial growth factor; Kidney disease; Lymphatic system; Urinary system disease; Lymphatic density; Lymphatic; Malignant hemopathy; VEGF-C; Malignant tumor; Invasion; D2-40; Lymph node metastasis; Anatomic pathology; Vascular endothelium growth factor; Vascular endothelial growth factor C; Kidney cancer
• ISSN: 0002-9173; 1943-7722
• DOI: 10.1309/0FT8WTDKREFHHP4P

We studied the associations of lymphatic invasion and lymphatic vessel density around tumors with lymph node (LN) status in renal cell carcinoma (RCC) by immunohistochemical analysis using D2-40 antibody as a lymphatic marker. Surgically removed specimens from 76 cases with RCC, including 16 cases with LN metastasis, were used. Lymphatic vessel density around the tumor increased compared with normal kidneys but was not significant by LN status. Tumor size, tumor cell types, patterns of tumor growth, nuclear grade of tumor cells, venous invasion, lymphatic invasion, and primary tumor stage were predictive factors for LN metastasis. Based on multivariate regression analysis, only lymphatic invasion was an independent risk factor for LN metastasis. The immunohistochemical detection of lymphatics was useful for identifying the lymphatic invasion of RCC, and the presence of lymphatic invasion around RCC was an independent predictive factor for LN metastasis.