Regulation of human lipolysis. In vivo observations on the role of adrenergic receptors

Changes in the plasma free fatty acids of a pancreatectomized subject and in free fatty acids and insulin in 10 normal subjects in response to the in vivo infusion of epinephrine alone, epinephrine plus phentolamine, and epinephrine plus propranolol indicate that both alpha and beta adrenergic recep...

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Bibliographic Details
Published inThe Journal of clinical investigation Vol. 53; no. 1; pp. 338 - 341
Main Authors Burns, T W, Mohs, J M, Langley, P E, Yawn, R, Chase, G R
Format Journal Article
LanguageEnglish
Published United States 01.01.1974
Subjects
Adipose Tissue - drug effects
Adult
Blood Glucose - metabolism
Blood Pressure - drug effects
Epinephrine - administration & dosage
Epinephrine - pharmacology
Fatty Acids, Nonesterified - blood
Glycerol - blood
Humans
Insulin - blood
Male
Pancreatectomy
Phentolamine - administration & dosage
Phentolamine - pharmacology
Propranolol - administration & dosage
Propranolol - pharmacology
Time Factors
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Summary:Changes in the plasma free fatty acids of a pancreatectomized subject and in free fatty acids and insulin in 10 normal subjects in response to the in vivo infusion of epinephrine alone, epinephrine plus phentolamine, and epinephrine plus propranolol indicate that both alpha and beta adrenergic receptors are present in human adipose tissue. Under the experimental conditions used, adipose tissue appeared to be more responsive to epinephrine than did the cardiovascular system.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI107556