Relative monocyte count is associated with metabolic syndrome and other cardiometabolic risk markers in subjects at Secondary Health Care: a cross-sectional study

• Published in: Diabetes research and clinical practice Vol. 226; p. 112341
• Main Authors: Cândido, Flávia Galvão, da Silva, Alessandra, Oliveira, Nathallia Maria Cotta e, Zanirate, Gilmara Alves, Hermsdorff, Helen Hermana Miranda
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.08.2025
• Subjects: Adult; Aged; Biomarkers - blood; Cardiometabolic Risk Factors; Cardiovascular Diseases - blood; Cardiovascular Diseases - epidemiology; Central obesity; Cross-Sectional Studies; Female; Humans; Insulin resistance; Leukocyte Count; Male; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - epidemiology; Middle Aged; Monocytes; Risk Factors; Secondary Care; Visceral fat; Visceral fat; NCEP-ATPIII; WHtR; AIP; RMC; IDF; Metabolic syndrome; WC; DAAT; HTGW phenotype; Insulin resistance; LAP; Central obesity; VAI
• ISSN: 0168-8227; 1872-8227; 1872-8227
• DOI: 10.1016/j.diabres.2025.112341

[Display omitted] •Low RMC is associated with obesity-related disorders.•RMC and diabetes link suggests monocytes are more tied to poor glycemic control.•RMC helps identify individuals with high cardiovascular risk. Background: Relative monocyte count (RMC) is a low-cost widely used biomarker with the potential to predict obesity-related health risks. However, high cardiovascular risk could affect white blood cell dynamics. So, we aimed to investigate the associations between RMC with cardiometabolic risk markers in subjects at secondary prevention. Methods: This cross-sectional survey involved 687 subjects at Secondary Health Care. The cardiometabolic risk markers were obesity, metabolic syndrome, high waist circumference, high waist-to-height ratio, hypertension, diabetes, dyslipidemia, high glycated hemoglobin, waist-hypertriglyceridemic phenotype 1 and 2, visceral adiposity index, atherogenic index of plasma, lipid accumulation product, and deep-abdominal-adipose-tissue. Pearson’s chi-square test, binomial, and multiple Logistic regression were adopted (α = 0.05). Results: The first tertile of RMC (<5.20 %) was associated with higher odds of metabolic syndrome (OR 1.62; 95 %CI 1.10–2.17 for NCEP-ATPIII criteria and OR 1.48; 95 %CI 1.01–2.33 for IDF), diabetes (OR 1.68; 95 %CI 1.02–2.76), high glycated hemoglobin (OR 2.31; 95 %CI 1.16–4.59), hypertriglyceridemia (OR 1.57; 95 %CI 1.02–2.40), and waist-hypertriglyceridemic phenotype 1 (OR 1.58; 95 %CI 1.04–2.40) and 2 (OR 1.83; 95 %CI 1.17–2.88), compared to the third tertile, regardless of confounders. Conclusion: The lower RMC tertile was associated with higher odds of cardiometabolic disorders in subjects at secondary prevention.