Comparison of enzymatic kinetic resolution in a batch reactor and a CSTR

The difference between a continuous stirred-tank reactor (CSTR) and a batchwise reactor has been shown for the enzymatic kinetic resolution of enantiomers. By macroscopic reactor balancing new quantitative relationships between enzyme enantioselectivity, substrate or product enantiomeric excess, and...

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Bibliographic Details
Published inEnzyme and microbial technology Vol. 16; no. 9; pp. 791 - 794
Main Authors Rakels, J.L.L., Paffen, H.T., Straathof, A.J.J., Heijnen, J.J.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Inc 1994
Elsevier Science
Subjects
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
CSTR
enantioselectivity
Fundamental and applied biological sciences. Psychology
Kinetic resolution
membrane reactor
Methods. Procedures. Technologies
enantioselectivity
CSTR
Kinetic resolution
membrane reactor
Performance evaluation
Enantioselectivity
Enzyme
Esterases
Continuous stirred tank reactor
Continuous process
Membrane reactor
Bioreactor
Batchwise
Optical resolution
Enantiomer
Hydrolases
Enantiomeric excess
Kinetic parameter
Immobilized enzyme
Comparative study
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Summary:The difference between a continuous stirred-tank reactor (CSTR) and a batchwise reactor has been shown for the enzymatic kinetic resolution of enantiomers. By macroscopic reactor balancing new quantitative relationships between enzyme enantioselectivity, substrate or product enantiomeric excess, and the extent of conversion have been deduced for chiral resolution in a CSTR. They were experimentally verified for the esterase-catalyzed resolution of racemic methyl 2-chloropropionate. This reaction was performed both in a batch system and in an enzyme membrane reactor functioning as a CSTR. As expected, the batchwise reaction was superior.
ISSN:0141-0229
1879-0909
DOI:10.1016/0141-0229(94)90037-X