Utilization of a compaction simulator to formulate mini-tablets containing high dose of acyclovir

• Published in: Journal of drug delivery science and technology Vol. 64; p. 102602
• Main Authors: Cho, Cheol-Hee, Kim, Ju-Young, Park, Eun-Seok
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.08.2021
• Subjects: Compaction simulator; Compression energy; Ejection force; Elastic energy; Mini-tablet; Tensile strength; Compression energy; Ejection force; Elastic energy; Tensile strength; Mini-tablet; Compaction simulator
• ISSN: 1773-2247
• DOI: 10.1016/j.jddst.2021.102602

In this research, compaction simulator was utilized to develop high drug-loaded minitablet formulation. The formulation factors (type and ratio of filler, lubricant amount) and process factors (compression pressure, compression rate) were adjusted and the ejection force, tensile strength, thickness, compression energy, and elastic energy of mini-tablet were evaluated. The pregelatinized starch was found to be suitable base filler based on its ejection force reducing ability. When the high level of lubricant was used, tensile strength was negatively affected due to the hindrance effect. The compression pressure and compression rate influenced the ejection force by engaging in the residual die wall stress and mobility of lubricant. Meanwhile, investigation on the energy values suggested the high elasticity of pregelatinized starch. The optimized formulation could produce mini-tablets with acceptable ejection force, mechanical strength, aspect ratio, and release profile within the wide range of compression pressure and compression rate. [Display omitted] •Mini-tablet containing high amount of acyclovir was developed.•Formulation factors and process factors were adjusted.•Ejection force, tensile strength, thickness, energy values were evaluated.•Compaction simulator was a suitable tool for mini-tablet formulation development.