Cerebrospinal fluid outflow resistance in rabbits with experimental meningitis. Alterations with penicillin and methylprednisolone

• Published in: The Journal of clinical investigation Vol. 66; no. 2; pp. 243 - 253
• Main Authors: Scheld, W M, Dacey, R G, Winn, H R, Welsh, J E, Jane, J A, Sande, M A
• Format: Journal Article
• Language: English
• Published: United States 01.08.1980
• Subjects: Animals; Disease Models, Animal; Escherichia coli; Hydrostatic Pressure; Intracranial Pressure - drug effects; Meningitis - cerebrospinal fluid; Meningitis - drug therapy; Meningitis - physiopathology; Meningitis, Pneumococcal - cerebrospinal fluid; Meningitis, Pneumococcal - physiopathology; Methylprednisolone - therapeutic use; Penicillins - therapeutic use; Rabbits; Rheology
• ISSN: 0021-9738
• DOI: 10.1172/JCI109850

Acute bacterial meningitis may be associated with increased intracranial pressure, neurological sequelae such as communicating hydrocephalus, and a slow response to antibiotic therapy. Alterations in cerebrospinal hydrodynamics are at least partially responsible for these complications. Constant, low-flow short-duration manometric infusion studies through a hollow-bore pressure monitoring device in direct continuity with the supracortical subarachnoid space were performed in rabbits with experimental meningitis. Maximal resistance to cerebrospinal fluid (CSF) outflow from the subarachnoid to vascular space was markedly increaed in acute pneumococcal meningitis when compared to control, uninfected animals (6.77 +/- 3.52 vs. 0.26 +/- 0.04 mm Hg/microliter per min, P less than 0.001). Similar elevations (8.93 +/- 4.15 mm Hg/microliter per min were found in experimental Escherichia coli meningitis. Despite eradication of viable bacteria from the CSF by penicillin therapy during the acute stage of pneumococcal meningitis, resistance remained elevated (6.07 +/- 4.68 mm Hg/microliter per min) and had not returned to normal up to 15 d later. Administration of methylprednisolone during the early stages of acute pneumococcal meningitis reduced mean peak outflow resistance towards control values (0.59 mm Hg/microliter per min) and no "rebound" effect was apparent 24 h later. These hydrodynamic alterations in experimental meningitis prevent normal CSF absorption and decrease the ability of the bran to compensate for changes in intracranial volume and pressure.