LARGE-SCALE SYNTHESIS OF THIO-GLUCOSE-CONJUGATED CHLORIN E6 FOR PHOTODYNAMIC THERAPY

Chlorin e6 is a heterocycle exhibiting spectral absorption in the 600-700 nm wavelength range used for photodynamic therapy (PDT). Herein, a sugar-conjugated chlorin e6 derivative was synthesized on a large scale. An alkyl spacer was fabricated by controlling the alkoxylation conditions between the...

Full description

Saved in:
Bibliographic Details
Published inHeterocycles Vol. 103; no. 2; pp. 1108 - 1115
Main Authors Nomoto, Akihiro, Yamaguchi, Hiroaki, Masuda, Masato, Hyakumura, Keisuke, Kodama, Shintaro, Osaki, Tomohiro, Okamoto, Yoshiharu, Tanaka, Mamoru, Kataoka, Hiromi, Narumi, Atsushi, Yoshimura, Tomokazu, Yano, Shigenobu, Ogawa, Akiya
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 01.01.2021
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Online AccessGet more information

Cover

More Information
Summary:Chlorin e6 is a heterocycle exhibiting spectral absorption in the 600-700 nm wavelength range used for photodynamic therapy (PDT). Herein, a sugar-conjugated chlorin e6 derivative was synthesized on a large scale. An alkyl spacer was fabricated by controlling the alkoxylation conditions between the thio-sugar and chlorin e6 and thio-glucose-conjugated chlorin e6 was successfully synthesized.
ISSN:0385-5414
1881-0942
DOI:10.3987/COM-20-S(K)73