Role of P2X receptors in positive inotropic effect of rat myocardium during ontogeny

Experiments with selective agonists and antagonists of purinoceptors allowed us to evaluate the subtype of P2X receptors. We showed that the myocardium of 14–100-day-old rats contains functionally active P2X 1 receptors. These receptors are involved in the realization of the positive inotropic effec...

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Published inBulletin of experimental biology and medicine Vol. 145; no. 2; pp. 174 - 176
Main Authors Zverev, A. A., Anikina, T. A., Sitdicov, F. G.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.02.2008
Springer Nature B.V
Subjects
Adenosine Triphosphate - analogs & derivatives
Adenosine Triphosphate - metabolism
Aging - physiology
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Heart - anatomy & histology
Heart - growth & development
Internal Medicine
Laboratory Medicine
Myocardial Contraction
Myocardium - metabolism
Pathology
Purinergic P2 Receptor Agonists
Purinergic P2 Receptor Antagonists
Rats
Receptors, Purinergic P2 - metabolism
Receptors, Purinergic P2X
myocardial contractility
ontogeny
P2X receptors
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Summary:Experiments with selective agonists and antagonists of purinoceptors allowed us to evaluate the subtype of P2X receptors. We showed that the myocardium of 14–100-day-old rats contains functionally active P2X 1 receptors. These receptors are involved in the realization of the positive inotropic effect of the atria and ventricles. Selective P2X 1 receptor agonist β,γ-methylene-ATP induced a dose-dependent increase in the strength of atrial and ventricular contractions. P2X 1 receptor antagonist TNP-ATP abolished the effect of the agonist in rats of all age groups.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-008-0042-5