Response of chemokine antagonists to inflammation in injured spinal cord

• Published in: Neurochemical research Vol. 28; no. 1; pp. 95 - 100
• Main Authors: ENG, Lawrence F, YUEN LING LEE
• Format: Journal Article
• Language: English
• Published: New York, NY Springer 2003; Springer Nature B.V
• Subjects: Animal models; Animals; Anti-Inflammatory Agents - therapeutic use; Antibodies; Autoimmune diseases; Biological and medical sciences; Central nervous system; Chemokines; Chemokines - antagonists & inhibitors; Chemokines - physiology; Fundamental and applied biological sciences. Psychology; Humans; Hypersensitivity; Infiltration; Inflammation; Inflammatory response; Injury prevention; Leukocytes; Monocytes; Pain perception; Receptors; Spinal cord; Spinal cord injuries; Spinal Cord Injuries - drug therapy; Spinal Cord Injuries - pathology; Spinal Cord Injuries - physiopathology; Trauma; monocytes; CNS; Inflammation; receptors; chemokines
• ISSN: 0364-3190; 1573-6903
• DOI: 10.1023/A:1021652229667

Inflammation is a primary reaction to infection, allergic disorders, autoimmune diseases, and mechanical injury. The goal of an inflammatory response is to rapidly respond to noxious stimuli, such as trauma or pathogen, with a controlled amplification of cellular activation to eliminate, control, or wall off the triggering agent. Although the inflammatory response is necessary for resolution of the pathogenic event, by stander or collateral tissue damage is caused by the toxic nature of many of its by-products. It is characterized by the infiltration of leukocytes into the affected area. Chemokines and their receptors play an essential role as mediators of leukocyte infiltration. In most cases this response is so vigorous that its control, especially in the central nervous system, would inhibit recovery. The benefits of anti-inflammatory therapy based on interference with the chemokine system has been established in animal models and is being pursued with chemokine antibodies and receptor antagonists. Prolonged treatment with a broad-spectrum chemokine antagonist, vMIPII, has been shown to reduce the rate of infiltration of monocytes into injured rat spinal cord and promote survival.