FEM Optimization of Energy Density in Tumor Hyperthermia Using Time-Dependent Magnetic Nanoparticle Power Dissipation

• Published in: IEEE transactions on magnetics Vol. 50; no. 10; pp. 1 - 7
• Main Authors: Koch, Caleb Maxwel, Winfrey, A. Leigh
• Format: Journal Article
• Language: English
• Published: New York IEEE 01.10.2014; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Computer simulation; Constants; Finite element analysis; Heating; Hyperthermia; Magnetism; Mathematical model; Maximum power; Microprocessors; Nanoparticles; Nanostructure; Power dissipation; Tumors; treatment planning; Hyperthermia optimization; finite-element modeling; magnetic nanoparticles
• ISSN: 0018-9464; 1941-0069
• DOI: 10.1109/TMAG.2014.2331031

General principles are developed using a finite element model regarding how time-dependent power dissipation of magnetic nanoparticles can be used to optimize hyperthermia selectivity. To make the simulation more realistic, the finite size and spatial location of each individual nanoparticle is taken into consideration. When energy input into the system and duration of treatment is held constant, increasing the maximum power dissipation of nanoparticles increases concentrations of energy in the tumor. Furthermore, when the power dissipation of magnetic nanoparticles rises linearly, the temperature gradient on the edge of the tumor increases exponentially. With energy input held constant, the location and duration of maximum power dissipation in the treatment time scheme will affect the final energy concentration inside the tumor. Finally, connections are made between the simulation results and optimization of the design of nanoparticle power dissipation time-schemes for hyperthermia.