Fabrication of sample target plate for MALDI-TOF MS using proton beam writing

Ion beam irradiation of silicon followed by electrochemical etching has been used to produce fluid anchor points on a sample target plate for matrix assisted laser desorption ionization mass spectrometry. Non-porous areas on the fabricated target plate serve as anchor points for sample deposition. H...

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Bibliographic Details
Published inNuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms Vol. 249; no. 1-2; pp. 715 - 718
Main Authors Ressine, A., Auzelyte, V., Kristiansson, P., Marko-Varga, G., Laurell, T.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.08.2006
Subjects
Anchor chip
Engineering and Technology
MALDI-TOF MS analysis
Medical Engineering
Medicinteknik
Porous silicon
Proton beam writing
Sample target
Superhydrophobic surface
Teknik
81.05.Rm
Sample target
MALDI-TOF MS analysis
Superhydrophobic surface
81.20.Wk
06.60.Ei
82.80.Rt
Anchor chip
Porous silicon
Proton beam writing
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Summary:Ion beam irradiation of silicon followed by electrochemical etching has been used to produce fluid anchor points on a sample target plate for matrix assisted laser desorption ionization mass spectrometry. Non-porous areas on the fabricated target plate serve as anchor points for sample deposition. High hydrophobicity of the macroporous silicon surface surrounding anchor points intrinsically led to a better sample confinement and gave the possibility to deposit large volumes of sample at predefined spot areas, improving the sensitivity in bioanalyte readout. We also have found that irradiation with beam fluences lower than 1014cm−2 led to the enhanced anodization rate producing inverse structures.
ISSN:0168-583X
1872-9584
DOI:10.1016/j.nimb.2006.03.124