Dynamics of branched tissue assembly

The assembly of cells into tissues is a complex process controlled by numerous signaling pathways to ensure the fidelity of the final structure. Tissue assembly is also very dynamic, as exemplified by the formation of branched organs. Here we present two examples of tissue assembly in branched syste...

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Published inStem cell research & therapy Vol. 3; no. 5; p. 42
Main Authors Manivannan, Sriram, Nelson, Celeste M
Format Journal Article
LanguageEnglish
Published England BioMed Central 31.10.2012
Subjects
Animals
Drosophila melanogaster
Female
Mammary Glands, Animal - growth & development
Mice
Organogenesis - physiology
Review
Trachea - growth & development
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Summary:The assembly of cells into tissues is a complex process controlled by numerous signaling pathways to ensure the fidelity of the final structure. Tissue assembly is also very dynamic, as exemplified by the formation of branched organs. Here we present two examples of tissue assembly in branched systems that highlight this dynamic nature: formation of the tracheal network in Drosophila melanogaster and the ducts of the mammary gland in mice. Extension of the branches during tracheal development is a stereotyped process that produces identical organ geometries across individuals, whereas elongation of the ducts of the pubertal mammary gland is a non-stereotyped process that produces unique patterns. By studying these two organs, we can begin to understand the dynamic nature of development of other stereotyped and non-stereotyped branching systems, including the lung, kidney, and salivary gland.
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ISSN:1757-6512
1757-6512
DOI:10.1186/scrt133