Decreased prevalence of peripheral nerve pathology by electrodiagnostic testing in Gulf War veterans

• Published in: Military medicine Vol. 169; no. 11; pp. 868 - 871
• Main Authors: Joseph, Thomas K, Foster, Leslie, Pasquina, Paul F
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.11.2004
• Subjects: Adult; Electrodiagnosis; Female; Gulf War; Humans; Male; Military Personnel - statistics & numerical data; Peripheral Nerves - pathology; Peripheral Nervous System Diseases - diagnosis; Peripheral Nervous System Diseases - epidemiology; Persian Gulf Syndrome - diagnosis; Persian Gulf Syndrome - epidemiology; Prevalence; Retrospective Studies; United States - epidemiology; Veterans; Veterans - statistics & numerical data; United States
• ISSN: 0026-4075; 1930-613X
• DOI: 10.7205/MILMED.169.11.868

The objective was to report the results of electrodiagnostic testing performed on 56 U.S. Persian Gulf War (GW) veterans versus 120 U.S. non-Persian Gulf War (N-GW) patients referred to a physical medicine and rehabilitation clinic. A retrospective review of medical records was conducted. Patient medical records of U.S. GW and N-GW patients were reviewed. Patient demographics, reason for consultation, and results of electrodiagnostic testing were extracted from both groups. Results were recorded as positive (abnormal) or negative (normal) occurrence of radiculopathy, generalized peripheral polyneuropathy, and mononeuropathy. The results were then compared using Fisher's exact test. Of the patients referred to rule out a radiculopathy, one of the GW patients (1 of 73) had a positive study, whereas 9 of 38 N-GW patients had positive studies (p = 0.000). There was no statistically significant difference between the two groups with respect to the presence of generalized peripheral polyneuropathy or mononeuropathy. This retrospective review of medical records reveals no objective evidence from electrodiagnostic testing of an increased incidence of neuromuscular disease in GW veteran patients compared with N-GW patients. On the contrary, our results reveal a statistically lower incidence of positive electrodiagnostic testing within the GW veteran group, suggesting a lower threshold for referral of GW veteran patients for electrodiagnostic testing than N-GW patients.