Urinary glicosaminoglycans levels in women with urinary tract infection and non urinary tract infection

• Published in: IOP conference series. Earth and environmental science Vol. 125; no. 1; pp. 12046 - 12050
• Main Authors: Pasaribu, H P, Hanifa, A, Tala, R Z, Ardiansyah, E, Simanjuntak, R Y, Effendy, I H
• Format: Journal Article
• Language: English
• Published: Bristol IOP Publishing 01.03.2018
• Subjects: Bladder; Epithelium; Glycosaminoglycans; Infections; Reproductive status; Urethra; Urinary tract; Urinary tract diseases; Urinary tract infections; Urine; Urogenital system
• ISSN: 1755-1307; 1755-1315
• DOI: 10.1088/1755-1315/125/1/012046

UTI is an infection that occurs in the urinary tract due to the proliferation of a microorganism. Female is fourteen times more vulnerable to UTI than male, because their urethra is shorter. Bladder epithelium is coated with a thin layer of glycosaminoglycans which act as a non-specific anti-adherence factor and nonspecific defense mechanisms against infection and can be found in the urine. An analytic study with cross sectional approach was conducted in 46 patients (23 with UTI and 23 non UTI) from June 2016 to determine differences in levels of urinary glycosaminoglycans between two groups. Urine samples were taken and tested for UTI and non UTI strips test. Laboratory examination of urine GAGs levels using ELISA kit for Human Glycosaminoglycans, then tabulated and analyzed using SPSS. The result showed no significant differences in the characteristics of women between two groups. There are significant differences in the mean levels of urinary GAGs in women with UTI compared with Non-UTI (69.74 ± 21.34; 21.39 ± 2.61 mg/l; p <0.001). There was no significant relationship between the sexual status and UTI incidence, with low odds ratio values and no significant difference in the mean of urinary glicosaminoglycans level based on sexual status.