Use of High-Pressure Liquid Chromatography for Monitoring Nucleotide Concentration in Human Blood: A Preliminary Study with Stored Blood Cell Suspensions

Abstract The development of high-pressure liquid chromatography has made available a new technique for monitoring nucleotide concentrations in biological materials sensitively, accurately, and rapidly. Because there appears to be a correlation between ATP concentrations and viability of stored blood...

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Published inClinical chemistry (Baltimore, Md.) Vol. 19; no. 8; pp. 919 - 922
Main Authors Brown, Phyllis R, Parks, R. E., Jr, Herod, Jane
Format Journal Article
LanguageEnglish
Published England Am Assoc Clin Chem 01.08.1973
Subjects
Adenine Nucleotides - blood
Blood Banks
Blood Preservation
Chromatography, Ion Exchange
Drug Stability
Humans
Methods
Time Factors
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Summary:Abstract The development of high-pressure liquid chromatography has made available a new technique for monitoring nucleotide concentrations in biological materials sensitively, accurately, and rapidly. Because there appears to be a correlation between ATP concentrations and viability of stored blood, a preliminary study was carried out on blood cell suspensions to evaluate the technique for possible use in blood banks, clinical laboratories, and research on preservatives for blood.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0009-9147
1530-8561
DOI:10.1093/clinchem/19.8.919