Remission of Metabolic Syndrome: A Study of 140 Patients Six Months after Roux-en-Y Gastric Bypass

• Published in: Obesity surgery Vol. 18; no. 5; pp. 601 - 606
• Main Authors: Rossi, Marçal, Barretto Ferreira da Silva, Renato, Chaves Alcântara, Geraldo, Regina, Paulo Fernando, Martin Bianco Rossi, Felipe, Serpa Neto, Ary, Zimberg Chehter, Ethel
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01.05.2008; Springer Nature B.V
• Subjects: Body Mass Index; Diabetes Mellitus - epidemiology; Female; Gastric Bypass; Gastrointestinal surgery; Humans; Hypertension - epidemiology; Lipoproteins, HDL - blood; Male; Medicine; Medicine & Public Health; Metabolic syndrome; Metabolic Syndrome - epidemiology; Obesity; Obesity, Morbid - epidemiology; Postoperative Period; Remission Induction; Research Article; Retrospective Studies; Surgery; Surgical outcomes; Triglycerides - blood; Metabolic syndrome; Gastric bypass; Bariatric surgery
• ISSN: 0960-8923; 1708-0428
• DOI: 10.1007/s11695-008-9468-0

Background Metabolic Syndrome (MS) is a complex disorder characterized by a number of cardiovascular risk factors usually associated with central fat deposition and insulin resistance. Nowadays, there are many different medical treatments to MS, including bariatric surgery, which improves all risk factors. The present study aims to evaluate the influence of gastric bypass in the improvement of risk factors associated with MS, during the postoperative (6 months). Methods This was a retrospective study of 140 patients submitted to gastric bypass. The sample was comprised of a female majority (79.3 %). The mean body mass index (BMI) was 44.17 kg/m 2 . We evaluated the weight of the subjects, the presence of diabetes mellitus and hypertension as comorbidities, as well as plasma levels of triglycerides (TG), total cholesterol and its fractions, and glycemia, in both preoperative and postoperative. Results The percentage of excess weight loss (%EWL) was similar in men and women, with an average of 67.82 ± 13.21%. Concerning impaired fasting glucose (≥100 mg/dl), 41 patients (95.3%) presented normal postoperative glycemia. There has been an improvement of every appraised parameter. The mean decrease in TG level was 66.33 mg/dl ( p  < 0.0001). Before the surgery, 47.1% were hypertensive; after it, only 15% continued in antihypertensive drug therapy ( p  < 0.0001). Otherwise, the only dissimilar variable between sexes was the high-density lipoprotein (HDL) level. Conclusion Gastric bypass is an effective method to improve the risk factors of metabolic syndrome in the morbidly obese.